Judi Allen, MSc PhD
The Allen laboratory investigates the host immune response to parasite infection with a particular focus on type 2 immunity, the response mammals characteristically make to large multicellular parasites (helminths). A major research theme of the lab has been to investigate the function of macrophages activated by type 2 cytokines and their role in anti-helminth immunity. Prof Allen’s research interests include the relationship of anti-helminth immunity to wound repair pathways, and understanding the challenges faced by the immune system during co-infection with both micro and macroparasites.
Recent key publications
Knipper, J.A., Willenborg, S., Brinckmann, J., Bloch, W., Maaß, T., Wagener, R., Krieg, T., Sutherland, T.E., Munitz, A., Rothenberg, M.E., Niehoff, A., Metzger, M., Migge, T., Richardson, R., Hammerschmidt, M., Allen, J.E. and Eming, S.A. (2015) IL-4Rα signaling in myeloid cells controls collagen fibril assembly in skin repair. Immunity. 43, 803-816. PMID 26474656
Sutherland, T.E., Logan, N., Rückerl, D., Humbles, A.A., Stockinger, B., Maizels, R.M. and Allen, J.E. (2014) Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage. Nat Immunol. 15, 1116-1125. PMID 25326751
Gundra, U.M., Girgis, N.M., Ruckerl, D., Jenkins, S., Ward, L.N., Kurtz, Z.D., Wiens, K.E., Tang, M.S., Basu-Roy, U., Mansukhani, A., Allen*, J.E. and Loke*, P. (2014) Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct Blood. 123, e110-e122. PMID 24695852