Dudek, M., Yang, N., Ruckshanthi, J.P.D., Williams, J., Borysiewicz, E., Wang, P., Adamson, A., Li, J., Bateman, J.F., White, M.R., Boot-Handford, R.P., Hoyland, J.A. and Meng, Q.-J. (2017) The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration. Ann Rheum Dis. 76, 576-584. PubMed

Dudek, M., Gossan, N., Yang, N., Im, H.J., Ruckshanthi, J.P.D., Yoshitane, H., Li, X., Jin, D., Wang, P., Boudiffa, M., Bellantuono, I., Fukada, Y., Boot-Handford, R.P. and Meng, Q.J. (2016) The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. J Clin Invest. 126, 365-76. PubMed

Smyllie, N.J., Pilorz, V., Boyd, J., Meng, Q.J., Saer, B., Chesham, J.E., Maywood, E.S., Krogager, T.P., Spiller, D., Boot-Handford, R., White, M., Hastings, M.H. and Loudon, A.S.I. (2016) Visualizing and quantifying intracellular behavior and abundance of the core circadian clock protein Period2 in suprachiasmatic neurons and fibroblasts. Curr Biol. 26, 1880-6. PubMed

Soul, J., Dunn, S.L., Hardingham, T.E., Boot-Handford, R.P. and Schwartz, J-M.  (2016) PhenomeScape: a Cytoscape app to identify differentially regulated sub-networks using known disease associations. Bioinformatics. 32, 3847-3849. PubMed

Cameron, T.L., Bell, K.M., Gresshoff, I.L., Sampurno, L., Mullan, L., Ermann, J., Glimcher, L.H., Boot-Handford, R.P. and Bateman, J.F. (2015).XBP1-independent UPR pathways suppress C/EBP- mediated chondrocyte differentiation in ER-stress related skeletal disease. PLoS Genetics. 11, e1005505. PubMed

Cameron, T., Gresshoff, I., Bell, K., Pirog, K., Sampurno, L., Hartley, C., Wilson, R., Boot-Handford, R.P., Glimcher, L., Briggs, M.D. and Bateman, J.F. (2015). Cartilage-Specific Ablation of XBP1 Signaling in Mouse Results in a Chondrodysplasia Characterized by Reduced Chondrocyte Proliferation and Delayed Cartilage Maturation and Mineralization. Osteoarthritis Cartilage. 23, 661-70. PubMed

Guo, B., Yang, N., Borysiewicz, E., Dudek, M., Williams, J.L., Li, J., Maywood, E.S., Adamson, A., Hastings, M.H., Bateman, J.F., White, M.R.H., Boot-Handford, R.P. and Meng, Q.J. (2015). Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway. Osteoarthritis Cartilage. Special Issue: Inflammation in Osteoarthritis. 23, 1981-1988. PubMed

Kung, L.H.-W., Rajpar, M.H., Preziosi, R., Briggs, M.D. and Boot-Handford, R.P.  (2015). Increased Classical Endoplasmic Reticulum Stress is Sufficient to Reduce Chondrocyte Proliferation Rate in the Growth Plate and Decrease Bone Growth. PLoS ONE. 10, e0117016. PubMed 

Soul, J., Hardingham, T.E., Boot-Handford, R.P. and Schwartz, J.M. (2015). PhenomeExpress: A refined network analysis of expression datasets by inclusion of known disease phenotypes. Sci Rep. 5, 8117. PubMed

Brookes, S.J., Barron, M.J., Boot-Handford, R., Kirkham, J. and Dixon, M.J. (2014). Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate. Hum Mol Genet. 23, 2468-80. PMC

Gossan, N., Boot-Handford, R. and Meng, Q.J. (2014). Ageing and osteoarthritis: a circadian rhythm connection.  BiogerontologyEpub ahead of print.

Bell, P.A., Wagener, R., Zaucke, F., Kock, M., Selley, J., Warwood, S., Knight, D., Boot-Handford, R.P., Thornton, D.J and Briggs, M.D. (2013). Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveal common and discrete disease signatures. Biol Open 2, 802-11. PubMed 

Gossan, N., Zeef, L., Hensman, J., Hughes, A., Bateman, J.F., Rowley, L., Little, C.B., Piggins, H.D., Rattray, M., Boot-Handford, R.P. and Meng, Q.J. (2013). The circadian clock in chondrocytes regulates genes controlling key aspects of cartilage homeostasis. Arthritis Rheum. doi: 10.1002/art.38035. PubMed

Gualeni, B., Rajpar, M.H., Kellogg, A., Arvan, P., Boot-Handford, R.P. and Briggs, M.D. (2013). A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth. Dis Model Mech. 6, 1414-25. ePub 

Hartley, C.L., Edwards, S., Mullan, L., Bell, P.A., Fresquet, M., Boot-Handford, R.P. and Briggs, M.D. (2013) Armet/Manf and Creld2 are components of a specialised ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases. Hum Mol Genet. in press ePub

Bell, P.A., Piróg, K.A., Fresquet, M., Thornton, D.J., Boot-Handford, R.P. and Briggs, M.D. (2012). The loss of matrilin-1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation. Arthritis Rheum. 64, 1529-39. PubMed

Kung, L., Rajpar, M.H., Briggs, M.D. and Boot-Handford, R.P. (2012) Hypertrophic Chondrocytes Have a Limited Capacity to Cope with Increases in Endoplasmic Reticulum Stress Without Triggering the Unfolded Protein Response. J Histochem Cytochem. Epub ahead of print PubMed

Suleman, F, Gualeni, B., Gregson, H.J., Leighton, M.P., Pirog, K.A., Edwards, S., Holden, P., Boot-Handford, R.P. and Briggs, M.D. (2012). A novel form of chondrocyte stress is triggered by a COMP mutation causing Pseudoachondroplasia. Hum Mutat. 33, 218-231. PubMed

Swingler, T.E., Wheeler, G., Carmont, V., Elliott, H.R., Barter, M.J., Abu-Elmagd, M., Donell, S.T., Boot-Handford, R.P., Hajihosseini, M.K., Münsterberg, A., Dalmay, T. and Young, D.A., Clark, I.M. (2012).  The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum. 64, 1909-19. PubMed

Plumb, D.A., Ferrara, L., Torbica, T., Knowles, L., Mironov, A.Jr., Kadler, K.E., Briggs, M.D., Boot-Handford, R.P. (2011). Collagen XXVII organises the pericellular matrix in the growth plate. PLoS ONE 6: e29422. doi:10.1371/journal.pone.0029422.

Scott, J. L., Gabrielides, C., Davidson, R. K., Swingler, T. E., Clark, I. M., Wallis, G. A., Boot-Handford, R. P., Kirkwood, T. B., Talyor, R. W., and Young, D. A. (2010) Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease, Ann Rheum Dis PubMed link.

Pirog, K. A., Jaka, O., Katakura, Y., Meadows, R. S., Kadler, K. E., Boot-Handford, R. P., and Briggs, M. D. (2010) A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia, Hum Mol Genet 19, 52-64 PubMed link.

Nundlall, S., Rajpar, M. H., Bell, P. A., Clowes, C., Zeeff, L. A., Gardner, B., Thornton, D. J., Boot-Handford, R. P., and Briggs, M. D. (2010) An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia, Cell Stress Chaperones PubMed link.

Boot-Handford, R. P., and Briggs, M. D. (2010) The unfolded protein response and its relevance to connective tissue diseases, Cell Tissue Res 339, 197-211 PubMed link.

Rajpar, M. H., McDermott, B., Kung, L., Eardley, R., Knowles, L., Heeran, M., Thornton, D. J., Wilson, R., Bateman, J. F., Poulsom, R., Arvan, P., Kadler, K. E., Briggs, M. D., and Boot-Handford, R. P. (2009) Targeted induction of endoplasmic reticulum stress induces cartilage pathology, PLoS Genet 5, e1000691 PubMed link.

Bateman, J. F., Boot-Handford, R. P., and Lamande, S. R. (2009) Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations, Nat Rev Genet 10, 173-83 PubMed link.

Park, H., Huxley-Jones, J., Boot-Handford, R. P., Bishop, P. N., Attwood, T. K., and Bella, J. (2008) LRRCE: a leucine-rich repeat cysteine capping motif unique to the chordate lineage, BMC Genomics 9, 599 PubMed link.

Meng, Q. J., Logunova, L., Maywood, E. S., Gallego, M., Lebiecki, J., Brown, T. M., Sladek, M., Semikhodskii, A. S., Glossop, N. R., Piggins, H. D., Chesham, J. E., Bechtold, D. A., Yoo, S. H., Takahashi, J. S., Virshup, D. M., Boot-Handford, R. P., Hastings, M. H., and Loudon, A. S. (2008) Setting clock speed in mammals: the CK1epsilontau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins, Neuron 58, 78-88 PubMed link.

Hyde, G., Boot-Handford, R. P., and Wallis, G. A. (2008) Col2a1 lineage tracing reveals that the meniscus of the knee joint has a complex cellular origin, J Anat 213, 531-8 PubMed link.

Hadfield, K. D., Rock, C. F., Inkson, C. A., Dallas, S. L., Sudre, L., Wallis, G. A., Boot-Handford, R. P., and Canfield, A. E. (2008) HtrA1 inhibits mineral deposition by osteoblasts: requirement for the protease and PDZ domains, The Journal of biological chemistry 283, 5928-38 PubMed link.

Brew, C. J., Clegg, P. D., Boot-Handford, R. P., Andrews, G., and Hardingham, T. (2008) Gene expression in human chondrocytes in late OA is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy, Ann Rheum Dis PubMed link.

Zhang, X., Boot-Handford, R. P., Huxley-Jones, J., Forse, L. N., Mould, A. P., Robertson, D. L., Lili, Athiyal, M., and Sarras, M. P. (2007) The collagens of hydra provide insight into the evolution of metazoan extracellular matrices, The Journal of biological chemistry 282, 6792-802 PubMed link.

Wang, X., Nadarajah, B., Robinson, A. C., McColl, B. W., Jin, J. W., Dajas-Bailador, F., Boot-Handford, R. P., and Tournier, C. (2007) Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death, Molecular and cellular biology 27, 7935-46 PubMed link.

Plumb, D. A., Dhir, V., Mironov, A., Ferrara, L., Poulsom, R., Kadler, K. E., Thornton, D. J., Briggs, M. D., and Boot-Handford, R. P. (2007) Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens, The Journal of biological chemistry 282, 12791-5 PubMed link.

Pirog-Garcia, K. A., Meadows, R. S., Knowles, L., Heinegard, D., Thornton, D. J., Kadler, K. E., Boot-Handford, R. P., and Briggs, M. D. (2007) Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP, Human molecular genetics 16, 2072-88 PubMed link.

Perera, D., Tilston, V., Hopwood, J. A., Barchi, M., Boot-Handford, R. P., and Taylor, S. S. (2007) Bub1 maintains centromeric cohesion by activation of the spindle checkpoint, Developmental cell 13, 566-79 PubMed link.

Loudon, A. S., Meng, Q. J., Maywood, E. S., Bechtold, D. A., Boot-Handford, R. P., and Hastings, M. H. (2007) The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species, Cold Spring Harb Symp Quant Biol 72, 261-71 PubMed link.

Leighton, M. P., Nundlall, S., Starborg, T., Meadows, R. S., Suleman, F., Knowles, L., Wagener, R., Thornton, D. J., Kadler, K. E., Boot-Handford, R. P., and Briggs, M. D. (2007) Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation, Human molecular genetics 16, 1728-41 PubMed link.

Kadler, K. E., Baldock, C., Bella, J., and Boot-Handford, R. P. (2007) Collagens at a glance, Journal of cell science 120, 1955-8 PubMed link.

Hyde, G., Dover, S., Aszodi, A., Wallis, G. A., and Boot-Handford, R. P. (2007) Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms, Developmental biology 304, 825-33 PubMed link.

Huxley-Jones, J., Robertson, D. L., and Boot-Handford, R. P. (2007) On the origins of the extracellular matrix in vertebrates, Matrix Biol 26, 2-11 PubMed link.

Huxley-Jones, J., Clarke, T. K., Beck, C., Toubaris, G., Robertson, D. L., and Boot-Handford, R. P. (2007) The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio, BMC evolutionary biology 7, 63 PubMed link.

Ho, M. S., Tsang, K. Y., Lo, R. L., Susic, M., Makitie, O., Chan, T. W., Ng, V. C., Sillence, D. O., Boot-Handford, R. P., Gibson, G., Cheung, K. M., Cole, W. G., Cheah, K. S., and Chan, D. (2007) COL10A1 nonsense and frame-shift mutations have a gain-of-function effect on the growth plate in human and mouse metaphyseal chondrodysplasia type Schmid, Human molecular genetics 16, 1201-15 PubMed link.

Wang, X., Finegan, K. G., Robinson, A. C., Knowles, L., Khosravi-Far, R., Hinchliffe, K. A., Boot-Handford, R. P., and Tournier, C. (2006) Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress, Cell death and differentiation 13, 2099-108 PubMed link.

Richardson, R. J., Dixon, J., Malhotra, S., Hardman, M. J., Knowles, L., Boot-Handford, R. P., Shore, P., Whitmarsh, A., and Dixon, M. J. (2006) Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch, Nature genetics 38, 1329-34 PubMed link.

Mould, A. P., McLeish, J. A., Huxley-Jones, J., Goonesinghe, A. C., Hurlstone, A. F., Boot-Handford, R. P., and Humphries, M. J. (2006) Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio), BMC cell biology 7, 24 PubMed link.

Zambelli, A., Mongiardini, E., Villegas, S. N., Carri, N. G., Boot-Handford, R. P., and Wallis, G. A. (2005) Transcription factor XBP-1 is expressed during osteoblast differentiation and is transcriptionally regulated by parathyroid hormone (PTH), Cell Biol Int 29, 647-53 PubMed link.

Wang, X., Merritt, A. J., Seyfried, J., Guo, C., Papadakis, E. S., Finegan, K. G., Kayahara, M., Dixon, J., Boot-Handford, R. P., Cartwright, E. J., Mayer, U., and Tournier, C. (2005) Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway, Molecular and cellular biology 25, 336-45 PubMed link.

Huxley-Jones, J., Apte, S. S., Robertson, D. L., and Boot-Handford, R. P. (2005) The characterisation of six ADAMTS proteases in the basal chordate Ciona intestinalis provides new insights into the vertebrate ADAMTS family, Int J Biochem Cell Biol 37, 1838-45 PubMed link.

Ewan, R., Huxley-Jones, J., Mould, A. P., Humphries, M. J., Robertson, D. L., and Boot-Handford, R. P. (2005) The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family, BMC evolutionary biology 5, 31 PubMed link.

Greig, E. R., Boot-Handford, R. P., Mani, V., and Sandle, G. I. (2004) Decreased expression of apical Na+ channels and basolateral Na+, K+-ATPase in ulcerative colitis, The Journal of pathology 204, 84-92 PubMed link.

Hoffman, L. M., Nix, D. A., Benson, B., Boot-Hanford, R., Gustafsson, E., Jamora, C., Menzies, A. S., Goh, K. L., Jensen, C. C., Gertler, F. B., Fuchs, E., Fassler, R., and Beckerle, M. C. (2003) Targeted disruption of the murine zyxin gene, Molecular and cellular biology 23, 70-9 PubMed link.

Greig, E. R., Mathialahan, T., Boot-Handford, R. P., and Sandle, G. I. (2003) Molecular and functional studies of electrogenic Na(+) transport in the distal colon and rectum of young and elderly subjects, Gut 52, 1607-15 PubMed link.

Collett, G., Wood, A., Alexander, M. Y., Varnum, B. C., Boot-Handford, R. P., Ohanian, V., Ohanian, J., Fridell, Y. W., and Canfield, A. E. (2003) Receptor tyrosine kinase Axl modulates the osteogenic differentiation of pericytes, Circulation research 92, 1123-9 PubMed link.

Boot-Handford, R. P., Tuckwell, D. S., Plumb, D. A., Rock, C. F., and Poulsom, R. (2003) A novel and highly conserved collagen (pro(alpha)1(XXVII)) with a unique expression pattern and unusual molecular characteristics establishes a new clade within the vertebrate fibrillar collagen family, The Journal of biological chemistry 278, 31067-77 PubMed link.

Boot-Handford, R. P., and Tuckwell, D. S. (2003) Fibrillar collagen: the key to vertebrate evolution? A tale of molecular incest, Bioessays 25, 142-51 PubMed link.

Greig, E. R., Baker, E. H., Mathialahan, T., Boot-Handford, R. P., and Sandle, G. I. (2002) Segmental variability of ENaC subunit expression in rat colon during dietary sodium depletion, Pflugers Arch 444, 476-83 PubMed link.

Chambers, D., Young, D. A., Howard, C., Thomas, J. T., Boam, D. S., Grant, M. E., Wallis, G. A., and Boot-Handford, R. P. (2002) An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene, FEBS letters 531, 505-8 PubMed link.

Canfield, A. E., Farrington, C., Dziobon, M. D., Boot-Handford, R. P., Heagerty, A. M., Kumar, S. N., and Roberts, I. S. (2002) The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study, The Journal of pathology 196, 228-34 PubMed link.

Gregory, C. A., Zabel, B., Grant, M. E., Boot-Handford, R. P., and Wallis, G. A. (2000) Equal expression of typ X collagen mRNA fom mutant and wild type COL10A1 alleles in growth plate cartilage from a patient with metaphyseal chondrodysplasia type Schmid, Journal of medical genetics 37, 627-9 PubMed link.

Green, H., Canfield, A. E., Hillarby, M. C., Grant, M. E., Boot-Handford, R. P., Freemont, A. J., and Wallis, G. A. (2000) The ribosomal protein QM is expressed differentially during vertebrate endochondral bone development, J Bone Miner Res 15, 1066-75 PubMed link.

Fowler, S. J., Jose, S., Zhang, X., Deutzmann, R., Sarras, M. P., and Boot-Handford, R. P. (2000) Characterization of hydra type IV collagen. Type IV collagen is essential for head regeneration and its expression is up-regulated upon exposure to glucose, The Journal of biological chemistry 275, 39589-99 PubMed link.

Deutzmann, R., Fowler, S., Zhang, X., Boone, K., Dexter, S., Boot-Handford, R. P., Rachel, R., and Sarras, M. P. (2000) Molecular, biochemical and functional analysis of a novel and developmentally important fibrillar collagen (Hcol-I) in hydra, Development (Cambridge, England) 127, 4669-80 PubMed link.

Canfield, A. E., Doherty, M. J., Kelly, V., Newman, B., Farrington, C., Grant, M. E., and Boot-Handford, R. P. (2000) Matrix Gla protein is differentially expressed during the deposition of a calcified matrix by vascular pericytes, FEBS letters 487, 267-71 PubMed link.

Canfield, A. E., Doherty, M. J., Wood, A. C., Farrington, C., Ashton, B., Begum, N., Harvey, B., Poole, A., Grant, M. E., and Boot-Handford, R. P. (2000) Role of pericytes in vascular calcification: a review, Zeitschrift fur Kardiologie 89 Suppl 2, 20-7 PubMed link.

Aszodi, A., Bateman, J. F., Gustafsson, E., Boot-Handford, R., and Fassler, R. (2000) Mammalian skeletogenesis and extracellular matrix: what can we learn from knockout mice?, Cell structure and function 25, 73-84 PubMed link.

Marks, D. S., Gregory, C. A., Wallis, G. A., Brass, A., Kadler, K. E., and Boot-Handford, R. P. (1999) Metaphyseal chondrodysplasia type Schmid mutations are predicted to occur in two distinct three-dimensional clusters within type X collagen NC1 domains that retain the ability to trimerize, The Journal of biological chemistry 274, 3632-41 PubMed link.

Boot-Handford, R. P., Michaelidis, T. M., Hillarby, M. C., Zambelli, A., Denton, J., Hoyland, J. A., Freemont, A. J., Grant, M. E., and Wallis, G. A. (1998) The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype, International journal of experimental pathology 79, 329-35 PubMed link.

Wallis, G. A., Rash, B., Sykes, B., Bonaventure, J., Maroteaux, P., Zabel, B., Wynne-Davies, R., Grant, M. E., and Boot-Handford, R. P. (1996) Mutations within the gene encoding the alpha 1 (X) chain of type X collagen (COL10A1) cause metaphyseal chondrodysplasia type Schmid but not several other forms of metaphyseal chondrodysplasia, Journal of medical genetics 33, 450-7 PubMed link.

Hillarby, M. C., King, K. E., Brady, G., Grant, M. E., Wallis, G. A., and Boot-Handford, R. P. (1996) Localization of gene expression during endochondral ossification, Annals of the New York Academy of Sciences 785, 263-6 PubMed link.