From October 1989 to September 1992, I was a PhD Student in the MRC Clinical Research Centre at Harrow investigating the molecular defects of type I collagen in osteogenesis imperfecta. From October 1992 to October 1993, I was a Research Fellow in the Division of Medical Genetics at UCLA/Cedars Sinai Medical Centre. This was a 3-year Training Fellowship in the UCLA Intercampus Medical Genetics Training Program and the project involved the genetic mapping of PSACH and MED mutations in large families with these diseases. In July 1995, I was awarded a Research Fellowship from the Arthritis Research Campaign and moved to the University of Manchester. In January 2004, I started a 5-year Wellcome Trust Senior Research Fellowship and during this Fellowship I studied the disease mechanisms of matrilin-3 and COMP mutations in vitro and generated of the first mouse models of PSACH-MED. In April 2008, I was awarded a 5-year renewal of my SRF.