Han, B., Newbould, M., Batra, G., Cheesman, E., Craigie, R.J., Mohamed, Z., Rigby, L., Padidela, R., Skae, M., Mironov, A., Stargorg, T., Kadler, K.E., Cosgrove, K.E., Banerjee, I. and Dunne, M.J. (2016) Islet cell nucleomegaly in defining the histopathology of congenital hyperinsulinism in infancy. Am J Clin Pathol. 145, 757-768. PubMed

Jones, F.E., Bailey. M.A., Murray, L.S., Lu, Y., McNeilly, S., Schloetzer-Schrehardt, U., Lennon, R., Sado, Y., Brownstein, D.G., Mullins, J.J., Kadler, K.E. and Van Agtmael, T. (2016). ER-stress and basement membrane defects combine to cause glomerular and tubular renal disease caused by Col4a1 mutations. Dis Model Mech. 9, 165-76. PubMed

Zigrino, P., Brinckmann, J., Niehoff, A., Lu, Y., Giebeler, N., Eckes, B., Kadler, K.E. and Mauch, C. (2016) Fibroblast-derived MMP-14 regulates collagen homeostasis in adult skin. J Investigat Dermatol. 136, 1575-83. PubMed 

Breidenbach, A.P., Aschbacher-Smith, L., Lu, Y., Dyment, N.A., Liu, C-F., Liu, H., Wylie, C., Rao, M., Shearn, J.T., Rowe, R.W., Kadler, K.E., Jiang, R. and Butler., D.L. (2015). Ablating hedgehog signalling in tenocytes during development impairs biomechanics and matrix organization of the adult murine patellar tendon enthesis. J Orthop Res. 33, 1142-51. PubMed

Breidenbach, A., Dyment, N., Lu, Y., Rao, M., Shearn, J., Rowe, D., Kadler, K. E., and Butler, D. (2015). Fibrin gels exhibit improved biological, structural and mechanical properties compared to collagen gels in cell-based tendon tissue engineered constructs. Tissue Eng Part A. 21, 438-50. PubMed

Herchenhan, A., Uhlenbrock, F., Eliasson, P., Weis, M., Eyre, D., Kadler, K.E. and Magnusson, S.P. and Kjaer, M. (2015). Lysyl oxidase activity is required for ordered collagen fibrillogenesis by tendon cells. J Biol Chem. 290, 16440-50. PubMed

Kalson, N., Lu, Y., Taylor, S., Starborg, T., Holmes, D. and Kadler, K. (2015). A structure-based extracellular matrix expansion mechanism of fibrous tissue growth. eLife.4: e05958. PubMed

Starborg, T. and Kadler, K.E. (2015). Serial block face-scanning electron microscopy: A tool for studying embryonic development at the cell-matrix interface. Birth Defects Res C Embryo Today. 105, 9-18. PubMed 

Taylor, S.H., Yeung, C.C., Kalson, N.S., Lu, Y., Zigrino, P., Starborg, T., Warwood, S., Holmes, D.F., Canty-Laird, E.G., Mauch, C. and Kadler, K.E. (2015). Matrix metalloproteinase 14 is required for fibrous tissue expansion. eLife. 4, e09345. PubMed

Kadler, K. E. (2014) The needle in the ECM haystack.  Nature Rev Mol Cell Biol. 15, 769. PubMed

Pingel, J., Lu, Y., Starborg, T., Fredberg, U., Langberg, H., Nedergaard, A., Weis, M., Eyre, D., Kjaer, M. and Kadler, K.E. (2014) .3-D ultrastructure and collagen composition of healthy and overloaded human tendon: evidence of tenocyte and matrix buckling. J Anat. 224, 548-55. ePub

Smith, R., McIlwraith, W., Schweitzer, R., Kadler, K., Cook, J., Caterson, B., Dakin, S., Heinegård, D., Screen, H., Stover, S., Crevier-Denoix, N., Clegg, P., Collins, M., Little, C., Frisbie, D., Kjaer, M., van Weeren, R., Werpy, N., Denoix, J.M., Carr, A., Goldberg, A., Bramlage, L., Smith, M. and Nixon, A. (2014). Advances in the understanding of tendinopathies: a report on the Second Havemeyer Workshop on equine tendon disease. Equine Vet J. 46, 4-9.  PubMed

Yeung, C-Y., C., Gossan, N., Lu, Y., Hughes, A., Hensman, J. J., Bayer, M., Kjaer, M., Kadler, K. E. and Meng, Q-J. (2014). Gremlin-2 is a BMP antagonist that is regulated by the circadian clock. Scientific Reports. 4, 5183. PubMed

*Yeung, C.-Y. C., Taylor, S. H., Garva, R., Holmes, D. F., Zeef, L. A., Soininen, R., Boot-Handford, R. P. and *Kadler, K. E. (2014). Arhgap28 Is a RhoGAP that inactivates RhoA and downregulates stress fibers. PLoS ONE 9: e107036. *Equal corresponding authors. PubMed

Young, R.D., Knupp, C., Pinali, C., Png, K.M., Ralphs, J.R., Bushby, A.J., Starborg, T., Kadler, K.E. and Quantock, A.J. (2014). Three-dimensional aspects of matrix assembly by cells in the developing cornea. Proc Natl Acad Sci U S A. 111, 687-92. PMC

Goh, K.L., Holmes, D.F., Lu, Y., Purslow, P.P., Kadler, K.E., Bechet, D. and Wess, T.J. (2012).Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture. J Appl Physiol. 113, 878-88. PubMed

 

Guerquin, M-J., Charvet, B., Nourissat, G., Havis, E., Ronsin, O., Bonnin, M-A., Ruggiu, M., Olivera, I., Robert, N., Lu, Y., Kadler, K. E., Baumberger, T., Doursounian, L., Berenbaum, F. and Duprez, D. (2013) Egr1 directs tendon differentiation promotes tendon repair.  J Clin Invest. 123, 3564-76. PubMed 

 

Murray, L., Taggart, A., Abramowicz, M., Vilain, C., Van Regemorter, N., Lu, Y., Kadler, K. E., and Van Agtmael, T. (2013) Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke. Hum Mol Genet. in press ePub

 

Starborg, T.,  Kalson, N.S., Lu, Y., Mironov, A., Cootes, T.F., Holmes, D.F. and Kadler, K.E. (2013). Collagen fibril size and three-dimensional organization by electron microscopy: a protocol for TEM and 3View. Nat Protoc. 8, 1433-1448. PubMed

 

Canty-Laird EG, Lu Y, Kadler KE. (2011). Step-wise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts in situ. Biochem J. Epub PubMed.

 

Herchenhan A, Kalson NS, Holmes DF, Hill P, Kadler KE, Margetts L. (2011). Tenocyte contraction induces crimp formation in tendon-like tissue. Biomech Model Mechanobiol., July 7 PubMed link.

 

Kalson, N., Holmes, D., Lu, Y., Herchenhan, A., Starborg, T., Kadler, K. (2011). Slow stretching that mimics embryonic growth rate stimulates structural and mechanical development of tendon-like tissue in vitro. Developmental Dynamics 240, 2520-8. doi: 10.1002/dvdy.22760. PubMed link

 

Plumb, D.A., Ferrara, L., Torbica, T., Knowles, L., Mironov, A.Jr., Kadler, K.E., Briggs, M.D., Boot-Handford, R.P. (2011). Collagen XXVII organises the pericellular matrix in the growth plate. PLoS ONE 6: e29422. doi:10.1371/journal.pone.0029422.

Taylor, S. H., Al-Youha, S., Van Agtmael, T., Lu, Y., Wong, J., McGrouther, D. A., & Kadler, K. E. (2011). Tendon Is Covered by a Basement Membrane Epithelium That Is Required for Cell Retention and the Prevention of Adhesion Formation.PLoS One, doi:10.1371/journal.pone.0016337. PLoS

 

Wong, J. K., Alyouha, S., Kadler, K. E., Ferguson, M. W., and McGrouther, D. A. (2010) The cell biology of suturing tendons, Matrix Biol PubMed link.

Pirog, K. A., Jaka, O., Katakura, Y., Meadows, R. S., Kadler, K. E., Boot-Handford, R. P., and Briggs, M. D. (2010) A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia, Hum Mol Genet 19, 52-64 PubMed link.

Kalson, N. S., Holmes, D. F., Kapacee, Z., Otermin, I., Liu, Y., Ennos, R. A., and Kadler, K. E. (2010) An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery, Matrix Biol PubMed link.

Inforzato, A., Baldock, C., Jowitt, T. A., Holmes, D. F., Lindstedt, R., Marcellini, M., Rivieccio, V., Briggs, D. C., Kadler, K. E., Verdoliva, A., Bottazzi, B., Mantovani, A., Salvatori, G., and Day, A. J. (2010) The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2, J Biol Chem PubMed link.

Holmes, D. F., Tait, A., Hodson, N. W., Sherratt, M. J., and Kadler, K. E. (2010) Growth of collagen fibril seeds from embryonic tendon: fractured fibril ends nucleate new tip growth, J Mol Biol 399, 9-16 PubMed link.

Canty-Laird, E., Carre, G. A., Mandon-Pepin, B., Kadler, K. E., and Fabre, S. (2010) First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles, Biol Reprod 83, 138-46 PubMed link.

Berry, R., Jowitt, T. A., Garrigue-Antar, L., Kadler, K. E., and Baldock, C. (2010) Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase, FEBS Lett 584, 657-661 PubMed link.

Bayer, M. L., Yeung, C. Y., Kadler, K. E., Qvortrup, K., Baar, K., Svensson, R. B., Magnusson, S. P., Krogsgaard, M., Koch, M., and Kjaer, M. (2010) The initiation of embryonic-like collagen fibrillogenesis by adult human tendon fibroblasts when cultured under tension, Biomaterials 31, 4889-97 PubMed link.

Wong, J. K., Lui, Y. H., Kapacee, Z., Kadler, K. E., Ferguson, M. W., and McGrouther, D. A. (2009) The cellular biology of flexor tendon adhesion formation: an old problem in a new paradigm, Am J Pathol 175, 1938-51 PubMed link.

Starborg, T., Lu, Y., Huffman, A., Holmes, D. F., and Kadler, K. E. (2009) Electron microscope 3D reconstruction of branched collagen fibrils in vivo, Scand J Med Sci Sports 19, 547-52 PubMed link.

Rajpar, M. H., McDermott, B., Kung, L., Eardley, R., Knowles, L., Heeran, M., Thornton, D. J., Wilson, R., Bateman, J. F., Poulsom, R., Arvan, P., Kadler, K. E., Briggs, M. D., and Boot-Handford, R. P. (2009) Targeted induction of endoplasmic reticulum stress induces cartilage pathology, PLoS Genet 5, e1000691 PubMed link.

Berry, R., Jowitt, T. A., Ferrand, J., Roessle, M., Grossmann, J. G., Canty-Laird, E. G., Kammerer, R. A., Kadler, K. E., and Baldock, C. (2009) Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid, Proc Natl Acad Sci U S A 106, 8561-6 PubMed link.

Vaughan-Thomas, A., Dudhia, J., Bayliss, M. T., Kadler, K. E., and Duance, V. C. (2008) Modification of the composition of articular cartilage collagen fibrils with increasing age, Connect Tissue Res 49, 374-82 PubMed link.

Starborg, T., Lu, Y., Kadler, K. E., and Holmes, D. F. (2008) Electron microscopy of collagen fibril structure in vitro and in vivo including three-dimensional reconstruction, Methods in cell biology 88, 319-45 PubMed link.

Starborg, T., Lu, Y., Meadows, R. S., Kadler, K. E., and Holmes, D. F. (2008) Electron microscopy in cell-matrix research, Methods (San Diego, Calif 45, 53-64 PubMed link.

Peacock, J. D., Lu, Y., Koch, M., Kadler, K. E., and Lincoln, J. (2008) Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance, Dev Dyn 237, 3051-8 PubMed link.

Levay, A. K., Peacock, J. D., Lu, Y., Koch, M., Hinton, R. B., Kadler, K. E., and Lincoln, J. (2008) Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo, Circ Res 103, 948-56 PubMed link.

Kapacee, Z., Richardson, S. H., Lu, Y., Starborg, T., Holmes, D. F., Baar, K., and Kadler, K. E. (2008) Tension is required for fibripositor formation, Matrix Biol 27, 371-5 PubMed link.

Kadler, K. E., Hill, A., and Canty-Laird, E. G. (2008) Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators, Current opinion in cell biology PubMed link.

Humphries, S. M., Lu, Y., Canty, E. G., and Kadler, K. E. (2008) Active negative control of collagen fibrillogenesis in vivo. Intracellular cleavage of the type I procollagen propeptides in tendon fibroblasts without intracellular fibrils, J Biol Chem 283, 12129-35 PubMed link.

Goh, K. L., Holmes, D. F., Lu, H. Y., Richardson, S., Kadler, K. E., Purslow, P. P., and Wess, T. J. (2008) Ageing changes in the tensile properties of tendons: influence of collagen fibril volume fraction, Journal of biomechanical engineering 130, 021011 PubMed link.

Richardson, S. H., Starborg, T., Lu, Y., Humphries, S. M., Meadows, R. S., and Kadler, K. E. (2007) Tendon development requires regulation of cell condensation and cell shape via cadherin-11-mediated cell-cell junctions, Molecular and cellular biology 27, 6218-28 PubMed link.

Plumb, D. A., Dhir, V., Mironov, A., Ferrara, L., Poulsom, R., Kadler, K. E., Thornton, D. J., Briggs, M. D., and Boot-Handford, R. P. (2007) Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens, The Journal of biological chemistry 282, 12791-5 PubMed link.

Pirog-Garcia, K. A., Meadows, R. S., Knowles, L., Heinegard, D., Thornton, D. J., Kadler, K. E., Boot-Handford, R. P., and Briggs, M. D. (2007) Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP, Human molecular genetics 16, 2072-88 PubMed link.

Leighton, M. P., Nundlall, S., Starborg, T., Meadows, R. S., Suleman, F., Knowles, L., Wagener, R., Thornton, D. J., Kadler, K. E., Boot-Handford, R. P., and Briggs, M. D. (2007) Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation, Human molecular genetics 16, 1728-41 PubMed link.

Kadler, K. E., Baldock, C., Bella, J., and Boot-Handford, R. P. (2007) Collagens at a glance, Journal of cell science 120, 1955-8 PubMed link.

Kadler, K. (2007) Collagen pretzels revealed by electron microscopy, The Biochemical journal 404, e7-8 PubMed link.

Holmes, D. F., and Kadler, K. E. (2006) The 10+4 microfibril structure of thin cartilage fibrils, Proceedings of the National Academy of Sciences of the United States of America 103, 17249-54 PubMed link.

Canty, E. G., Garrigue-Antar, L., and Kadler, K. E. (2006) A complete domain structure of Drosophila tolloid is required for cleavage of short gastrulation, The Journal of biological chemistry 281, 13258-67 PubMed link.

Canty, E. G., Starborg, T., Lu, Y., Humphries, S. M., Holmes, D. F., Meadows, R. S., Huffman, A., O'Toole, E. T., and Kadler, K. E. (2006) Actin filaments are required for fibripositor-mediated collagen fibril alignment in tendon, The Journal of biological chemistry 281, 38592-8 PubMed link.

Petropoulou, V., Garrigue-Antar, L., and Kadler, K. E. (2005) Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1), J Biol Chem 280, 22616-23 PubMed link.

Holmes, D. F., and Kadler, K. E. (2005) The precision of lateral size control in the assembly of corneal collagen fibrils, J Mol Biol 345, 773-84 PubMed link.

Goh, K. L., Hiller, J., Haston, J. L., Holmes, D. F., Kadler, K. E., Murdoch, A., Meakin, J. R., and Wess, T. J. (2005) Analysis of collagen fibril diameter distribution in connective tissues using small-angle X-ray scattering, Biochim Biophys Acta 1722, 183-8 PubMed link.

Canty, E. G., and Kadler, K. E. (2005) Procollagen trafficking, processing and fibrillogenesis, J Cell Sci 118, 1341-53 PubMed link.

Kadler, K. (2004) Matrix loading: assembly of extracellular matrix collagen fibrils during embryogenesis, Birth Defects Res C Embryo Today 72, 1-11 PubMed link.

Garrigue-Antar, L., Francois, V., and Kadler, K. E. (2004) Deletion of epidermal growth factor-like domains converts mammalian tolloid into a chordinase and effective procollagen C-proteinase, J Biol Chem 279, 49835-41 PubMed link.

Canty, E. G., Lu, Y., Meadows, R. S., Shaw, M. K., Holmes, D. F., and Kadler, K. E. (2004) Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon, J Cell Biol 165, 553-63 PubMed link.

Bishop, P. N., Holmes, D. F., Kadler, K. E., McLeod, D., and Bos, K. J. (2004) Age-related changes on the surface of vitreous collagen fibrils, Investigative ophthalmology & visual science 45, 1041-6 PubMed link.

Leighton, M., and Kadler, K. E. (2003) Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network, J Biol Chem 278, 18478-84 PubMed link.

Hartigan, N., Garrigue-Antar, L., and Kadler, K. E. (2003) Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity, J Biol Chem 278, 18045-9 PubMed link.

Rattenholl, A., Pappano, W. N., Koch, M., Keene, D. R., Kadler, K. E., Sasaki, T., Timpl, R., Burgeson, R. E., Greenspan, D. S., and Bruckner-Tuderman, L. (2002) Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen, J Biol Chem 277, 26372-8 PubMed link.

Garrigue-Antar, L., Hartigan, N., and Kadler, K. E. (2002) Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein, J Biol Chem 277, 43327-34 PubMed link.

Canty, E. G., and Kadler, K. E. (2002) Collagen fibril biosynthesis in tendon: a review and recent insights, Comp Biochem Physiol A Mol Integr Physiol 133, 979-85 PubMed link.

Baldock, C., Gilpin, C. J., Koster, A. J., Ziese, U., Kadler, K. E., Kielty, C. M., and Holmes, D. F. (2002) Three-dimensional reconstructions of extracellular matrix polymers using automated electron tomography, Journal of structural biology 138, 130-6 PubMed link.

Holmes, D. F., Graham, H. K., Trotter, J. A., and Kadler, K. E. (2001) STEM/TEM studies of collagen fibril assembly, Micron 32, 273-85 PubMed link.

Holmes, D. F., Gilpin, C. J., Baldock, C., Ziese, U., Koster, A. J., and Kadler, K. E. (2001) Corneal collagen fibril structure in three dimensions: Structural insights into fibril assembly, mechanical properties, and tissue organization, Proceedings of the National Academy of Sciences of the United States of America 98, 7307-12 PubMed link.

Holden, P., Meadows, R. S., Chapman, K. L., Grant, M. E., Kadler, K. E., and Briggs, M. D. (2001) Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family, The Journal of biological chemistry 276, 6046-55 PubMed link.

Garrigue-Antar, L., Barker, C., and Kadler, K. E. (2001) Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity, J Biol Chem 276, 26237-42 PubMed link.

Bos, K. J., Holmes, D. F., Kadler, K. E., McLeod, D., Morris, N. P., and Bishop, P. N. (2001) Axial structure of the heterotypic collagen fibrils of vitreous humour and cartilage, J Mol Biol 306, 1011-22 PubMed link.

Bos, K. J., Holmes, D. F., Meadows, R. S., Kadler, K. E., McLeod, D., and Bishop, P. N. (2001) Collagen fibril organisation in mammalian vitreous by freeze etch/rotary shadowing electron microscopy, Micron 32, 301-6 PubMed link.

Baldock, C., Koster, A. J., Ziese, U., Rock, M. J., Sherratt, M. J., Kadler, K. E., Shuttleworth, C. A., and Kielty, C. M. (2001) The supramolecular organization of fibrillin-rich microfibrils, The Journal of cell biology 152, 1045-56 PubMed link.

Trotter, J. A., Kadler, K. E., and Holmes, D. F. (2000) Echinoderm collagen fibrils grow by surface-nucleation-and-propagation from both centers and ends, J Mol Biol 300, 531-40 PubMed link.

Trotter, J. A., Tipper, J., Lyons-Levy, G., Chino, K., Heuer, A. H., Liu, Z., Mrksich, M., Hodneland, C., Dillmore, W. S., Koob, T. J., Koob-Emunds, M. M., Kadler, K., and Holmes, D. (2000) Towards a fibrous composite with dynamically controlled stiffness: lessons from echinoderms, Biochem Soc Trans 28, 357-62 PubMed link.