Karl Kadler, BSc PhD
My laboratory is focused on understanding the elusive mechanisms whereby cells make soft viscoelastic tissues.
Viscoelasticity is most evident in young skin, tendons and ligaments that return to their original state when deformed. Loss of these mechanical properties occurs with age, scarring, vascular disease, and occurs in some heritable disorders of connective tissues. We have developed methods of measuring the viscoelastic properties of tissue equivalents grown in the laboratory. We can also regulate gene expression in these equivalents and use microscopy techniques to examine cell migration and tissue formation. We are combining these techniques to identify the genes responsible for establishing and maintaining the mechanical properties of soft tissues. Our aim is to translate our discoveries into treatments for fibrosis, scarring, and vascular disease, and to improve healing of soft tissues such as tendons, ligaments and skin.
Tel: +44 (0) 161 275 5086
Recent key publications
Starborg, T., Kalson, N.S., Lu, Y., Mironov, A., Cootes, T.F., Holmes, D.F. and Kadler, K.E. (2013). Collagen fibril size and three-dimensional organization by electron microscopy: a protocol for TEM and 3View. Nature Protocols in press.
Canty-Laird, E.G., Lu, Y., Kadler, K.E. (2011). Step-wise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts in situ. Biochem J. 441, 707-17. PubMed.
Taylor, S. H., Al-Youha, S., Van Agtmael, T., Lu, Y., Wong, J., McGrouther, D. A., & Kadler, K. E. (2011). Tendon Is Covered by a Basement Membrane Epithelium That Is Required for Cell Retention and the Prevention of Adhesion Formation.PLoS One, doi:10.1371/journal.pone.0016337. PLoS