Karl Kadler, BSc PhD
Collagen fibrils

The research in my laboratory is focused on understanding how cells synthesise an extracellular matrix containing organised collagen fibrils. The fibrils account for 30% of the mass of vertebrates and are the mechanical framework for all fibrous and hard tissues, as well as organs such as skin, gut and muscle. Collagen fibrils are the end-point of fibrosis (of heart, liver, skin and kidney) in which functional tissue is replaced by dense collagen. We want to understand how and where collagen fibrils are assembled with the aim of controlling this process in the treatment of fibrotic disease. We have shown that the circadian clock regulates gene expression in fibrous tissues leading to collagen pathologies including calcific tendinopathy.

For reviews of our research see The circadian clock in tendon 2014, Collagen fibril transport at the plasma membrane 2013, Collagen imaging 2013, Collagen fibrillogenesis 2008, Collagens at a Glance 2007, Procollagen trafficking 2005, Collagen fibril formation 1996.

For all publications on PubMed, click here

Recent discoveries:

Matrix metalloproteinase 14 is required for fibrous tissue expansion

Recent key publications

Pringel, J., Lu, Y., Starborg, T., Fredberg, U., Langberg, H., Nedergaard, A., Eyre, D., Kjær, M. and Kadler, K. E. (2014). Cell and matrix buckling in overload-induced tendinopathy. J Anatomy. ePub

Kalson, N.S., Starborg, T., Lu, Y., Mironov, A., Humphries, S.M., Holmes, D.F. and Kadler, K.E. (2013) Non-muscle myosin II powered transport of newly-formed collagen fibrils at the plasma membrane. PNAS. 110, E4743-52. PubMed

Starborg, T.,  Kalson, N.S., Lu, Y., Mironov, A., Cootes, T.F., Holmes, D.F. and Kadler, K.E. (2013). Collagen fibril size and three-dimensional organization by electron microscopy: a protocol for TEM and 3View. Nat Protoc. 8, 1433-1448. PubMed

Full list of publications