Yeo, G.C., Baldock, C.,  Tuukkanen, A.,  Roessle, M.,  Dyksterhuis, L.B.,  Wise, S.G.,  Matthews, J.,  Mithieux, S.M.,  Weiss, A.S.(2012). The tropoelastin bridge region positions the cell-interactive C-terminus and contributes to elastic fiber assembly.Proc Natl Acad Sci U S A., 109, 2878-2883. PubMed

 

Baldock C, Oberhauser AF, Ma L, Lammie D, Siegler V, Mithieux SM, Tu Y, Chow JY, Suleman F, Malfois M, Rogers S, Guo L, Irving TC, Wess TJ, Weiss AS.(2011) Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity. PNASMar 15;108(11):4322-7. Epub 2011 Feb 28.PNAS

 

Beecher, N., Roseman, A.M., Jowitt, T.A., Berry, R., Troilo, H., Kammerer, R.A., Shuttleworth, C.A., Kielty, C.M., Baldock, C. (2011). Collagen VI: Conformation of A-domain arrays and microfibril architecture. J Biol Chem. Epub PubMed.

 

Rhys, N. H., Wang, M. C., Jowitt, T. A., Helliwell, J. R., Grossmann, J. G., & Baldock, C. (2011). Deriving the ultrastructure of α-crustacyanin using lower-resolution structural and biophysical methods. Journal of Synchrotron Radiation18(1), 79-83. doi:10.1107/S0909049510034977. PubMed link

 

Tooley, L. D., Zamurs, L. K., Beecher, N., Baker, N. L., Peat, R. A., Adams, N. E., Bateman, J. F., North, K. N., Baldock, C., and Lamande, S. R. (2010) Collagen VI microfibril formation is abolished by an α2(VI) von Willebrand factor A-domain mutation in a patient with Ullrich congenital muscular dystrophy, J Biol Chem PubMed link.

Massam-Wu, T., Chiu, M., Choudhury, R., Chaudhry, S. S., Baldwin, A. K., McGovern, A., Baldock, C., Shuttleworth, C. A., and Kielty, C. M. (2010) Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta, J Cell Sci 123, 3006-18 PubMed link.

Jowitt, T. A., Murdoch, A. D., Baldock, C., Berry, R., Day, J. M., and Hardingham, T. E. (2010) Order within disorder: Aggrecan chondroitin sulphate-attachment region provides new structural insights into protein sequences classified as disordered, Proteins PubMed link.

Inforzato, A., Baldock, C., Jowitt, T. A., Holmes, D. F., Lindstedt, R., Marcellini, M., Rivieccio, V., Briggs, D. C., Kadler, K. E., Verdoliva, A., Bottazzi, B., Mantovani, A., Salvatori, G., and Day, A. J. (2010) The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2, J Biol Chem PubMed link.

Berry, R., Jowitt, T. A., Garrigue-Antar, L., Kadler, K. E., and Baldock, C. (2010) Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase, FEBS Lett 584, 657-661 PubMed link.

Wang, M. C., Lu, Y., and Baldock, C. (2009) Fibrillin microfibrils: a key role for the interbead region in elasticity, J Mol Biol 388, 168-79 PubMed link.

Jones, R. P., Ridley, C., Jowitt, T. A., Wang, M. C., Howard, M., Bobola, N., Wang, T., Bishop, P. N., Kielty, C. M., Baldock, C., Lotery, A., and Trump, D. (2009) Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa, Invest Ophthalmol Vis Sci PubMed link.

Jones, R. P., Wang, M. C., Jowitt, T. A., Ridley, C., Mellody, K. T., Howard, M., Wang, T., Bishop, P. N., Lotery, A. J., Kielty, C. M., Baldock, C., and Trump, D. (2009) Fibulin 5 forms a compact dimer in physiological solutions, J Biol Chem 284, 25938-43 PubMed link.

Hill, R., Mo, Z., Haque, M., and Baldock, C. (2009) An evaluation of ionization chambers for the relative dosimetry of kilovoltage x-ray beams, Med Phys 36, 3971-81 PubMed link.

Choudhury, R., McGovern, A., Ridley, C., Cain, S. A., Baldwin, A., Wang, M. C., Guo, C., Mironov, A., Drymoussi, Z., Trump, D., Shuttleworth, A., Baldock, C., and Kielty, C. M. (2009) Differential regulation of elastic fiber formation by fibulin-4 and -5, J Biol Chem 284, 24553-67 PubMed link.

Cain, S. A., McGovern, A., Small, E., Ward, L. J., Baldock, C., Shuttleworth, A., and Kielty, C. M. (2009) Defining elastic fiber interactions by molecular fishing: an affinity purification and mass spectrometry approach, Mol Cell Proteomics 8, 2715-32 PubMed link.

Berry, R., Jowitt, T. A., Ferrand, J., Roessle, M., Grossmann, J. G., Canty-Laird, E. G., Kammerer, R. A., Kadler, K. E., and Baldock, C. (2009) Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid, Proc Natl Acad Sci U S A 106, 8561-6 PubMed link.

Little, H. J., Rorick, N. K., Su, L. I., Baldock, C., Malhotra, S., Jowitt, T., Gakhar, L., Subramanian, R., Schutte, B. C., Dixon, M. J., and Shore, P. (2008) Mis-sense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6, Hum Mol Genet PubMed link.

Fdez, E., Jowitt, T. A., Wang, M. C., Rajebhosale, M., Foster, K., Bella, J., Baldock, C., Woodman, P. G., and Hilfiker, S. (2008) A role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex dimerization during neurosecretion, Mol Biol Cell 19, 3379-89 PubMed link.

Sherratt, M. J., Baldock, C., Morgan, A., and Kielty, C. M. (2007) The morphology of adsorbed extracellular matrix assemblies is critically dependent on solution calcium concentration, Matrix Biol 26, 156-66 PubMed link.

Kadler, K. E., Baldock, C., Bella, J., and Boot-Handford, R. P. (2007) Collagens at a glance, Journal of cell science 120, 1955-8 PubMed link.

Dyksterhuis, L. B., Baldock, C., Lammie, D., Wess, T. J., and Weiss, A. S. (2007) Domains 17-27 of tropoelastin contain key regions of contact for coacervation and contain an unusual turn-containing crosslinking domain, Matrix Biol 26, 125-35 PubMed link.

Robinson, P. N., Arteaga-Solis, E., Baldock, C., Collod-Beroud, G., Booms, P., De Paepe, A., Dietz, H. C., Guo, G., Handford, P. A., Judge, D. P., Kielty, C. M., Loeys, B., Milewicz, D. M., Ney, A., Ramirez, F., Reinhardt, D. P., Tiedemann, K., Whiteman, P., and Godfrey, M. (2006) The molecular genetics of Marfan syndrome and related disorders, Journal of medical genetics 43, 769-87 PubMed link.

Mellody, K. T., Freeman, L. J., Baldock, C., Jowitt, T. A., Siegler, V., Raynal, B. D., Cain, S. A., Wess, T. J., Shuttleworth, C. A., and Kielty, C. M. (2006) Marfan syndrome-causing mutations in fibrillin-1 result in gross morphological alterations and highlight the structural importance of the second hybrid domain, The Journal of biological chemistry 281, 31854-62 PubMed link.

Lu, Y., Sherratt, M. J., Wang, M. C., and Baldock, C. (2006) Tissue specific differences in fibrillin microfibrils analysed using single particle image analysis, Journal of structural biology 155, 285-93 PubMed link.

Knupp, C., Pinali, C., Munro, P. M., Gruber, H. E., Sherratt, M. J., Baldock, C., and Squire, J. M. (2006) Structural correlation between collagen VI microfibrils and collagen VI banded aggregates, Journal of structural biology 154, 312-26 PubMed link.

Knupp, C., Pinali, C., Munro, P. M., Gruber, H. E., Sherratt, M. J., Baldock, C., and Squire, J. M. (2006) Reprint of "Structural correlation between collagen VI microfibrils and collagen VI banded aggregates" [J. Struct. Biol. 154 (2006) 312-326], Journal of structural biology 155, 379-93 PubMed link.

Baldock, C., Siegler, V., Bax, D. V., Cain, S. A., Mellody, K. T., Marson, A., Haston, J. L., Berry, R., Wang, M. C., Grossmann, J. G., Roessle, M., Kielty, C. M., and Wess, T. J. (2006) Nanostructure of fibrillin-1 reveals compact conformation of EGF arrays and mechanism for extensibility, Proceedings of the National Academy of Sciences of the United States of America 103, 11922-7 PubMed link.

Marson, A., Rock, M. J., Cain, S. A., Freeman, L. J., Morgan, A., Mellody, K., Shuttleworth, C. A., Baldock, C., and Kielty, C. M. (2005) Homotypic fibrillin-1 interactions in microfibril assembly, The Journal of biological chemistry 280, 5013-21 PubMed link.

Lu, Y., Holmes, D. F., and Baldock, C. (2005) Evidence for the intramolecular pleating model of fibrillin microfibril organisation from single particle image analysis, Journal of molecular biology 349, 73-85 PubMed link.

Kielty, C. M., Sherratt, M. J., Marson, A., and Baldock, C. (2005) Fibrillin microfibrils, Advances in protein chemistry 70, 405-36 PubMed link.

Cain, S. A., Baldock, C., Gallagher, J., Morgan, A., Bax, D. V., Weiss, A. S., Shuttleworth, C. A., and Kielty, C. M. (2005) Fibrillin-1 interactions with heparin. Implications for microfibril and elastic fiber assembly, The Journal of biological chemistry 280, 30526-37 PubMed link.

Jackson, G. C., Barker, F. S., Jakkula, E., Czarny-Ratajczak, M., Makitie, O., Cole, W. G., Wright, M. J., Smithson, S. F., Suri, M., Rogala, P., Mortier, G. R., Baldock, C., Wallace, A., Elles, R., Ala-Kokko, L., and Briggs, M. D. (2004) Missense mutations in the beta strands of the single A-domain of matrilin-3 result in multiple epiphyseal dysplasia, Journal of medical genetics 41, 52-9 PubMed link.

Sherratt, M. J., Baldock, C., Haston, J. L., Holmes, D. F., Jones, C. J., Shuttleworth, C. A., Wess, T. J., and Kielty, C. M. (2003) Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues, Journal of molecular biology 332, 183-93 PubMed link.

Haston, J. L., Engelsen, S. B., Roessle, M., Clarkson, J., Blanch, E. W., Baldock, C., Kielty, C. M., and Wess, T. J. (2003) Raman microscopy and X-ray diffraction, a combined study of fibrillin-rich microfibrillar elasticity, The Journal of biological chemistry 278, 41189-97 PubMed link.

Baldock, C., Sherratt, M. J., Shuttleworth, C. A., and Kielty, C. M. (2003) The supramolecular organization of collagen VI microfibrils, Journal of molecular biology 330, 297-307 PubMed link.

Roujeinikova, A., Baldock, C., Simon, W. J., Gilroy, J., Baker, P. J., Stuitje, A. R., Rice, D. W., Slabas, A. R., and Rafferty, J. B. (2002) X-ray crystallographic studies on butyryl-ACP reveal flexibility of the structure around a putative acyl chain binding site, Structure 10, 825-35 PubMed link.

Roujeinikova, A., Baldock, C., Simon, W. J., Gilroy, J., Baker, P. J., Stuitje, A. R., Rice, D. W., Rafferty, J. B., and Slabas, A. R. (2002) Crystallization and preliminary X-ray crystallographic studies on acyl-(acyl carrier protein) from Escherichia coli, Acta crystallographica 58, 330-2 PubMed link.

Kielty, C. M., Baldock, C., Lee, D., Rock, M. J., Ashworth, J. L., and Shuttleworth, C. A. (2002) Fibrillin: from microfibril assembly to biomechanical function, Philosophical transactions of the Royal Society of London 357, 207-17 PubMed link.

Baldock, C., Gilpin, C. J., Koster, A. J., Ziese, U., Kadler, K. E., Kielty, C. M., and Holmes, D. F. (2002) Three-dimensional reconstructions of extracellular matrix polymers using automated electron tomography, Journal of structural biology 138, 130-6 PubMed link.

Sherratt, M. J., Wess, T. J., Baldock, C., Ashworth, J., Purslow, P. P., Shuttleworth, C. A., and Kielty, C. M. (2001) Fibrillin-rich microfibrils of the extracellular matrix: ultrastructure and assembly, Micron 32, 185-200 PubMed link.

Levy, C. W., Baldock, C., Wallace, A. J., Sedelnikova, S., Viner, R. C., Clough, J. M., Stuitje, A. R., Slabas, A. R., Rice, D. W., and Rafferty, J. B. (2001) A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase, Journal of molecular biology 309, 171-80 PubMed link.

Holmes, D. F., Gilpin, C. J., Baldock, C., Ziese, U., Koster, A. J., and Kadler, K. E. (2001) Corneal collagen fibril structure in three dimensions: Structural insights into fibril assembly, mechanical properties, and tissue organization, Proceedings of the National Academy of Sciences of the United States of America 98, 7307-12 PubMed link.

Chaudhry, S. S., Gazzard, J., Baldock, C., Dixon, J., Rock, M. J., Skinner, G. C., Steel, K. P., Kielty, C. M., and Dixon, M. J. (2001) Mutation of the gene encoding fibrillin-2 results in syndactyly in mice, Human molecular genetics 10, 835-43 PubMed link.

Ball, S. G., Baldock, C., Kielty, C. M., and Shuttleworth, C. A. (2001) The role of the C1 and C2 a-domains in type VI collagen assembly, The Journal of biological chemistry 276, 7422-30 PubMed link.

Baldock, C., Koster, A. J., Ziese, U., Rock, M. J., Sherratt, M. J., Kadler, K. E., Shuttleworth, C. A., and Kielty, C. M. (2001) The supramolecular organization of fibrillin-rich microfibrils, The Journal of cell biology 152, 1045-56 PubMed link.

Shuttleworth, A., Ball, S., Baldock, C., Fakhoury, H., and Kielty, C. M. (1999) Functional role of A-domains in type VI collagen, Biochem Soc Trans 27, 821-3 PubMed link.

de Boer, G. J., Pielage, G. J., Nijkamp, H. J., Slabas, A. R., Rafferty, J. B., Baldock, C., Rice, D. W., and Stuitje, A. R. (1999) Molecular genetic analysis of enoyl-acyl carrier protein reductase inhibition by diazaborine, Molecular microbiology 31, 443-50 PubMed link.

Baldock, C., Rafferty, J. B., Stuitje, A. R., Slabas, A. R., and Rice, D. W. (1998) The X-ray structure of Escherichia coli enoyl reductase with bound NAD+ at 2.1 A resolution, Journal of molecular biology 284, 1529-46 PubMed link.

Baldock, C., Rafferty, J. B., Sedelnikova, S. E., Baker, P. J., Stuitje, A. R., Slabas, A. R., Hawkes, T. R., and Rice, D. W. (1996) A mechanism of drug action revealed by structural studies of enoyl reductase, Science (New York, N.Y 274, 2107-10 PubMed link.