Wang, P., Lindsay, J., Owens, T.W., Mularczyk, E.J., Warwood, S., Foster, F., Streuli, C.H.,  Brennan, K. and Gilmore, A.P. (2014). Phosphorylation of the pro-apoptotic BH3-only protein Bid primes mitochondria for apoptosis during mitotic arrest. Cell Reports in press.

Akhtar N, Streuli CH. (2013). An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium. Nat Cell Biol. 15, 17-27. PubMed

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Dos Santos Silva I, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM. (2013). Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res. 15, R92. PMC

Glukhova, M. and Streuli, C.H. (2013). Integrins in breast biology. Curr Opin Cell Biol. 25, 633-41. PubMed

Moreno-Layseca, P. and Streuli, C.H. (2013). Signalling pathways linking integrins with cell cycle progression. Matrix Biol. pii: S0945-053X(13)00140-6. ScienceDirect

Owens, T.W., Gilmore, A.P., Streuli, C.H. and Foster, F.M. (2013). Inhibitor of Apoptosis proteins: promising targets  for cancer therapy. Journal of Carcinogenesis and Mutagenesis S14-004. omics

Schellenberg, B., Keeble, J.A., Walker, S., Owens, T.W., Foster, F., Tanianis-Hughes, J., Brennan, K., Streuli, C.H. and Gilmore, A.P.  (2013). Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming. Mol Cell. 49, 959-71. PMC

Streuli, C.H. (2013). Cell adhesion in cancer. In: The Molecular Biology of Cancer, 2nd edition (Ed Pelengaris S, Kahn M). Wiley-Blackwell Publishing Inc, Chichester, UK. 383-409.

Jeanes, A.I., Wang, P., Moreno-Layseca, P., Paul, N., Cheung, J., Tsang, R., Akhtar, N., Foster, F.M., Brennan, K. and Streuli, C.H. (2012). Specific β-containing integrins exert differential control on proliferation and 2D collective cell migration in mammary epithelial cells. J. Biol. Chem. 287, 24103-12. PubMed

Du J-Y, Chen M-C, Hsu T-C, Wang J-H, Brackenbury L, Lin T-H, Yang Y, Streuli CH, Lee Y-J. (2011) The RhoA-Rok-myosin II pathway is involved in extracellular matrix mediated regulation of prolactin signaling in mammary epithelial cells. Journal of Cellular Physiology. Jun 15. doi: 10.1002/jcp.22886. PubMed link

Jeanes, A. I., Maya-Mendoza, A., & Streuli, C. H. (2011). Cellular microenvironment influences the ability of mammary epithelia to undergo cell cycle. PloS One, 6(3), e18144. doi:10.1371/journal.pone.0018144.PubMed link

 

Rooney, N., & Streuli, C. H. (2011). How integrins control mammary epithelial differentiation: A possible role for the ILK-PINCH-Parvin complex. FEBS Letters. doi:10.1016/j.febslet.2011.05.014. PubMed link

 

Streuli, C.H. (2012). Life and the matrix. Development 139, 4498-4499.

 

Wang P, Ballestrem C, Streuli CH. (2011). The C’-terminus of talin links integrins to cell cycle progression. J. Cell Biol. 195, 499-513. PubMed link

 

Owens, T. W., Foster, F. M., Tanianis-Hughes, J., Cheung, J. Y., Brackenbury, L., and Streuli, C. H. (2010) Analysis of inhibitor of apoptosis protein family expression during mammary gland development, BMC Dev Biol 10, 71 PubMed link.

Owens, T. W., Foster, F. M., Valentijn, A., Gilmore, A. P., and Streuli, C. H. (2010) Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization, J Biol Chem 285, 1081-8 PubMed link.

Muschler, J., and Streuli, C. H. (2010) Cell-Matrix Interactions in Mammary Gland Development and Breast Cancer, Cold Spring Harb Perspect Biol PubMed link.

Zouq, N. K., Keeble, J. A., Lindsay, J., Valentijn, A. J., Zhang, L., Mills, D., Turner, C. E., Streuli, C. H., and Gilmore, A. P. (2009) FAK engages multiple pathways to maintain survival of fibroblasts and epithelia - differential roles for paxillin and p130Cas, J Cell Sci 122, 357-67 PubMed link.

Streuli, C. H., and Akhtar, N. (2009) Signal co-operation between integrins and other receptor systems, Biochem J 418, 491-506 PubMed link.

Streuli, C. H. (2009) Integrins and cell-fate determination, J Cell Sci 122, 171-7 PubMed link.

Lee, Y. J., Hsu, T. C., Du, J. Y., Valentijn, A. J., Wu, T. Y., Cheng, C. F., Yang, Z., and Streuli, C. H. (2009) Extracellular matrix controls insulin signaling in mammary epithelial cells through the RhoA/Rok pathway, J Cell Physiol 220, 476-84 PubMed link.

Klinowska, T. C., and Streuli, C. H. (2009) Analyzing how Cell Adhesion Controls Mammary Gland Function by Transplantation of Embryonic Mammary Tissue from Knockout Mice, Methods Mol Biol 522, 1-15 PubMed link.

Duran-Jimenez, B., Dobler, D., Moffatt, S., Rabbani, N., Streuli, C. H., Thornalley, P. J., Tomlinson, D. R., and Gardiner, N. J. (2009) Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes, Diabetes 58, 2893-903 PubMed link.

Akhtar, N., Marlow, R., Lambert, E., Schatzmann, F., Lowe, E. T., Cheung, J., Katz, E., Li, W., Wu, C., Dedhar, S., Naylor, M. J., and Streuli, C. H. (2009) Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation, Development 136, 1019-27 PubMed link.

Thompson, A., Brennan, K., Cox, A., Gee, J., Harcourt, D., Harris, A., Harvie, M., Holen, I., Howell, A., Nicholson, R., Steel, M., and Streuli, C. (2008) Evaluation of the current knowledge limitations in breast cancer research: a gap analysis, Breast Cancer Res 10, R26 PubMed link.

Katz, E., and Streuli, C. H. (2007) The extracellular matrix as an adhesion checkpoint for mammary epithelial function, The international journal of biochemistry & cell biology 39, 715-26 PubMed link.

Gardiner, N. J., Moffatt, S., Fernyhough, P., Humphries, M. J., Streuli, C. H., and Tomlinson, D. R. (2007) Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin, Molecular and cellular neurosciences 35, 249-60 PubMed link.

Dowling, A. J., Waterfield, N. R., Hares, M. C., Le Goff, G., Streuli, C. H., and ffrench-Constant, R. H. (2007) The Mcf1 toxin induces apoptosis via the mitochondrial pathway and apoptosis is attenuated by mutation of the BH3-like domain, Cellular microbiology 9, 2470-84 PubMed link.

Akhtar, N., and Streuli, C. H. (2006) Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia, The Journal of cell biology 173, 781-93 PubMed link.

Naylor, M. J., Li, N., Cheung, J., Lowe, E. T., Lambert, E., Marlow, R., Wang, P., Schatzmann, F., Wintermantel, T., Schuetz, G., Clarke, A. R., Mueller, U., Hynes, N. E., and Streuli, C. H. (2005) Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation, J Cell Biol 171, 717-28 PubMed link.

Li, N., Zhang, Y., Naylor, M. J., Schatzmann, F., Maurer, F., Wintermantel, T., Schuetz, G., Mueller, U., Streuli, C. H., and Hynes, N. E. (2005) Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli, EMBO J 24, 1942-53 PubMed link.

Gardiner, N. J., Fernyhough, P., Tomlinson, D. R., Mayer, U., von der Mark, H., and Streuli, C. H. (2005) Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neurons, Mol Cell Neurosci 28, 229-40 PubMed link.

Zoubiane, G. S., Valentijn, A., Lowe, E. T., Akhtar, N., Bagley, S., Gilmore, A. P., and Streuli, C. H. (2004) A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation, Journal of cell science 117, 271-80 PubMed link.

Wang, P., Gilmore, A. P., and Streuli, C. H. (2004) Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrins, The Journal of biological chemistry 279, 41280-5 PubMed link.

Green, K. A., Naylor, M. J., Lowe, E. T., Wang, P., Marshman, E., and Streuli, C. H. (2004) Caspase-mediated Cleavage of Insulin Receptor Substrate, J Biol Chem 279, 25149-56 PubMed link.

Green, K. A., and Streuli, C. H. (2004) Apoptosis regulation in the mammary gland, Cell Mol Life Sci 61, 1867-83 PubMed link.

Dowling, A. J., Daborn, P. J., Waterfield, N. R., Wang, P., Streuli, C. H., and ffrench-Constant, R. H. (2004) The insecticidal toxin Makes caterpillars floppy (Mcf) promotes apoptosis in mammalian cells, Cell Microbiol 6, 345-53 PubMed link.

Wang, P., Valentijn, A. J., Gilmore, A. P., and Streuli, C. H. (2003) Early events in the anoikis program occur in the absence of caspase activation, The Journal of biological chemistry 278, 19917-25 PubMed link.

Valentijn, A. J., Metcalfe, A. D., Kott, J., Streuli, C. H., and Gilmore, A. P. (2003) Spatial and temporal changes in Bax subcellular localization during anoikis, The Journal of cell biology 162, 599-612 PubMed link.

Streuli, C. H. (2003) Cell adhesion in mammary gland biology and neoplasia, J Mammary Gland Biol Neoplasia 8, 375-81 PubMed link.

Schatzmann, F., Marlow, R., and Streuli, C. H. (2003) Integrin signaling and mammary cell function, J Mammary Gland Biol Neoplasia 8, 395-408 PubMed link.

Nicholson, K. M., Streuli, C. H., and Anderson, N. G. (2003) Autocrine signalling through erbB receptors promotes constitutive activation of protein kinase B/Akt in breast cancer cell lines, Breast Cancer Res Treat 81, 117-28 PubMed link.

Marshman, E., Green, K. A., Flint, D. J., White, A., Streuli, C. H., and Westwood, M. (2003) Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells, J Cell Sci 116, 675-82 PubMed link.

Watkin, H., and Streuli, C. H. (2002) Adenoviral-mediated gene transfer in two-dimensional and three-dimensional cultures of mammary epithelial cells, Methods Cell Biol 69, 403-23 PubMed link.

Tonko-Geymayer, S., Goupille, O., Tonko, M., Soratroi, C., Yoshimura, A., Streuli, C., Ziemiecki, A., Kofler, R., and Doppler, W. (2002) Regulation and function of the cytokine-inducible SH-2 domain proteins, CIS and SOCS3, in mammary epithelial cells, Mol Endocrinol 16, 1680-95 PubMed link.

Streuli, C. H. (2002) Maspin is a tumour suppressor that inhibits breast cancer tumour metastasis in vivo, Breast Cancer Res 4, 137-40 PubMed link.

Pu, Q. Q., and Streuli, C. H. (2002) Integrin control of cell cycle: a new role for ubiquitin ligase, Bioessays 24, 17-21 PubMed link.

Prince, J. M., Klinowska, T. C., Marshman, E., Lowe, E. T., Mayer, U., Miner, J., Aberdam, D., Vestweber, D., Gusterson, B., and Streuli, C. H. (2002) Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo, Dev Dyn 223, 497-516 PubMed link.

Marshman, E., and Streuli, C. H. (2002) Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function, Breast Cancer Res 4, 231-9 PubMed link.

Gilmore, A. P., Valentijn, A. J., Wang, P., Ranger, A. M., Bundred, N., O'Hare, M. J., Wakeling, A., Korsmeyer, S. J., and Streuli, C. H. (2002) Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor, The Journal of biological chemistry 277, 27643-50 PubMed link.

Klinowska, T. C., Alexander, C. M., Georges-Labouesse, E., Van der Neut, R., Kreidberg, J. A., Jones, C. J., Sonnenberg, A., and Streuli, C. H. (2001) Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits, Dev Biol 233, 449-67 PubMed link.

Hadjiloucas, I., Gilmore, A. P., Bundred, N. J., and Streuli, C. H. (2001) Assessment of apoptosis in human breast tissue using an antibody against the active form of caspase 3: relation to tumour histopathological characteristics, British journal of cancer 85, 1522-6 PubMed link.

Gilmore, A. P., Metcalfe, A. D., Romer, L. H., and Streuli, C. H. (2000) Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization, The Journal of cell biology 149, 431-46 PubMed link.

Costes, S., Streuli, C. H., and Barcellos-Hoff, M. H. (2000) Quantitative image analysis of laminin immunoreactivity in skin basement membrane irradiated with 1 GeV/nucleon iron particles, Radiat Res 154, 389-97 PubMed link.

Streuli, C. H., and Gilmore, A. P. (1999) Adhesion-mediated signaling in the regulation of mammary epithelial cell survival, Journal of mammary gland biology and neoplasia 4, 183-91 PubMed link.

Streuli, C. (1999) Extracellular matrix remodelling and cellular differentiation, Curr Opin Cell Biol 11, 634-40 PubMed link.

Mooney, A., Jackson, K., Bacon, R., Streuli, C., Edwards, G., Bassuk, J., and Savill, J. (1999) Type IV collagen and laminin regulate glomerular mesangial cell susceptibility to apoptosis via beta(1) integrin-mediated survival signals, Am J Pathol 155, 599-606 PubMed link.

Metcalfe, A. D., Gilmore, A., Klinowska, T., Oliver, J., Valentijn, A. J., Brown, R., Ross, A., MacGregor, G., Hickman, J. A., and Streuli, C. H. (1999) Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland, Journal of cell science 112 ( Pt 11), 1771-83 PubMed link.

Lee, Y. J., and Streuli, C. H. (1999) Extracellular matrix selectively modulates the response of mammary epithelial cells to different soluble signaling ligands, J Biol Chem 274, 22401-8 PubMed link.

Klinowska, T. C., Soriano, J. V., Edwards, G. M., Oliver, J. M., Valentijn, A. J., Montesano, R., and Streuli, C. H. (1999) Laminin and beta1 integrins are crucial for normal mammary gland development in the mouse, Dev Biol 215, 13-32 PubMed link.

Farrelly, N., Lee, Y. J., Oliver, J., Dive, C., and Streuli, C. H. (1999) Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling, J Cell Biol 144, 1337-48 PubMed link.

Taylor, M. F., Woolveridge, I., Metcalfe, A. D., Streuli, C. H., Hickman, J. A., and Morris, I. D. (1998) Leydig cell apoptosis in the rat testes after administration of the cytotoxin ethane dimethanesulphonate: role of the Bcl-2 family members, J Endocrinol 157, 317-26 PubMed link.

Streuli, C. H., and Edwards, G. M. (1998) Control of normal mammary epithelial phenotype by integrins, J Mammary Gland Biol Neoplasia 3, 151-63 PubMed link.

Jacques, T. S., Relvas, J. B., Nishimura, S., Pytela, R., Edwards, G. M., Streuli, C. H., and ffrench-Constant, C. (1998) Neural precursor cell chain migration and division are regulated through different beta1 integrins, Development 125, 3167-77 PubMed link.

Geng, L., Ali, S. A., Marshall, J. F., Mackay, C. L., Hart, I. R., Delcommence, M., Streuli, C. H., and Rees, R. C. (1998) Fibronectin is chemotactic for CT 26 colon carcinoma cells: sub-lines selected for increased chemotaxis to fibronectin display decreased tumorigenicity and lung colonization, Clin Exp Metastasis 16, 683-91 PubMed link.

Edwards, G. M., Wilford, F. H., Liu, X., Hennighausen, L., Djiane, J., and Streuli, C. H. (1998) Regulation of mammary differentiation by extracellular matrix involves protein-tyrosine phosphatases, J Biol Chem 273, 9495-500 PubMed link.

Milner, R., Frost, E., Nishimura, S., Delcommenne, M., Streuli, C., Pytela, R., and Ffrench-Constant, C. (1997) Expression of alpha vbeta3 and alpha vbeta8 integrins during oligodendrocyte precursor differentiation in the presence and absence of axons, Glia 21, 350-60 PubMed link.

Milner, R., Wilby, M., Nishimura, S., Boylen, K., Edwards, G., Fawcett, J., Streuli, C., Pytela, R., and ffrench-Constant, C. (1997) Division of labor of Schwann cell integrins during migration on peripheral nerve extracellular matrix ligands, Dev Biol 185, 215-28 PubMed link.

Metcalfe, A., and Streuli, C. (1997) Epithelial apoptosis, Bioessays 19, 711-20 PubMed link.

Brown, H. C., Castano, A., Fearn, S., Townsend, M., Edwards, G., Streuli, C., and Perry, V. H. (1997) Adhesion molecules involved in macrophage responses to Wallerian degeneration in the murine peripheral nervous system, Eur J Neurosci 9, 2057-63 PubMed link.

Pullan, S., Wilson, J., Metcalfe, A., Edwards, G. M., Goberdhan, N., Tilly, J., Hickman, J. A., Dive, C., and Streuli, C. H. (1996) Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium, J Cell Sci 109 ( Pt 3), 631-42 PubMed link.

Milner, R., Edwards, G., Streuli, C., and Ffrench-Constant, C. (1996) A role in migration for the alpha V beta 1 integrin expressed on oligodendrocyte precursors, J Neurosci 16, 7240-52 PubMed link.

Streuli, C. H., Edwards, G. M., Delcommenne, M., Whitelaw, C. B., Burdon, T. G., Schindler, C., and Watson, C. J. (1995) Stat5 as a target for regulation by extracellular matrix, J Biol Chem 270, 21639-44 PubMed link.

Streuli, C. H., Schmidhauser, C., Bailey, N., Yurchenco, P., Skubitz, A. P., Roskelley, C., and Bissell, M. J. (1995) Laminin mediates tissue-specific gene expression in mammary epithelia, J Cell Biol 129, 591-603 PubMed link.

Edwards, G., and Streuli, C. (1995) Signalling in extracellular-matrix-mediated control of epithelial cell phenotype, Biochem Soc Trans 23, 464-8 PubMed link.

Delcommenne, M., and Streuli, C. H. (1995) Control of integrin expression by extracellular matrix, J Biol Chem 270, 26794-801 PubMed link.