Research publications
Principal investigators in the Wellcome Trust Centre for Cell-Matix Research publish around 70 research articles annually. Publications for 2012 are listed below. Other years' publications are available via the links on the left-hand menu.
Alves-Silva, J., Sánchez-Soriano, N., Beaven, R., Klein, M., Parkin, J., Millard, T.H., Bellen, H.J., Venken, K.J., Ballestrem, C., Kammerer, R.A. and Prokop, A. (2012). Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins). J Neurosci. 32, 9143-58.PubMed
Ball, S.G., Shutteworth, C.A., Kielty, C.M. (2012). Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape and mesenchymal stem cell potency. Stem Cells 10.1002/stem.1015. PubMed
Barbier, D., Garcia-Verdugo, I., Pothlichet, J., Khazen, R., Descamps, D., Rousseau, K., Thornton, D., Si-Tahar, M., Touqui, L., Chignard, M. and Sallenave, J-M. (2012). Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-ERK-Sp1 dependent pathway. Am. J. Resp. Cell & Mol. Biol., 47, 149-57. PubMed
Bell PA, Piróg KA, Fresquet M, Thornton DJ, Boot-Handford RP, Briggs MD. (2012). The loss of matrilin-1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation. Arthritis Rheum. doi: 10.1002/art.33486. PubMed
Bridgewater, R.E., Norman, J.C., Caswell, P.T. (2012). Integrin trafficking at a glance. J Cell Sci. 125, 3695-701. PubMed
Byron, A., Humphries, J.D., Craig, S.E., Knight, D and Humphries, M.J. (2012). Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment. Proteomics 12, 2107-14. doi: 10.1002/pmic.201100487. PubMed
Byron, A., Humphries, J.D. and Humphries, M.J. (2012). Alternative cellular roles for proteins identified using proteomics. J. Proteomics 75, 4184-5. PubMed
Cain, S.A., McGovern, A., Baldwin, A.K., Baldock, C. Kielty, C.M. (2012). Fibrillin-1 mutations causing Weill-Marchesani syndrome and Acromicric and Geleophysic Dysplasias disrupt HS interactions. PLoS One, 7:e48634. doi: 10.1371/journal.pone.0048634. PubMed
Chang, M.Y., Chan, C.K., Braun, K.R., Green P.S., O’Brien, K.D., Chait, A., Day, A.J. & Wight, T.N. (2012). Monocyte to macrophage differentiation: synthesis and secretion of novel extraceullar matrix components. J. Biol. Chem., 287, 14122-35. PubMed
Collu, G.M., Hidalgo-Sastre, A., Gildea, C., Owens, T.W., Oliveira, S., Bayston, L.Dorey, K. and Brennan, K. (2012). Dishevelled limits Notch signalling through inhibition of CSL. Development, 139, 4405-15. doi: 10.1242/dev.081885. PubMed
Deakin, N.O., Ballestrem, C. and Turner, C.E. (2012). Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. PLoS One. 7, e37990. PubMed
Davies, J.R., Wickström, C., Thornton, D.J. (2012). Gel-forming and cell-associated mucins: preparation for structural and functional studies. Methods Mol Biol 842, 27-47. PubMed
Dozynkiewicz, M.A., Jamieson, N.B., MacPherson, I., Grindlay, J., van den Berghe, P., von Thun, A., Morton, J.P., Gourley, C., Timpson, P., Nixon, C., McKay, C.J., Carter, R., Strachan, Anderson, K., Sansom, O.J., Caswell, P.T., Norman, J.C.(2012). Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell. 22, 131-45. PubMed
Farnell, E., Rousseau, K., Thornton, D. J., Bowyer, P. and Herrick, S. (2012). Expression and secretion of Aspergillus fumigatus proteases is regulated in response to different protein substrates. Fungal Biology 11, 1003-12.
Ferguson, J., Arozarena, I., Ehrhardt, M., Wellbrock, C. (2012). Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion. Oncogene doi: 10.1038/onc.2012.25. PubMed
Giacomini, M.M., Travis, M.A., Kudo, K., Sheppard, D. (2012). Epithelial cells utilize cortical actin/myosin to activate latent TGF-beta through integrin alphav beta6-dependent physical force. Exp. Cell Res Epub ahead of print.PubMed
Goh, K.L., Holmes, D.F., Lu, Y., Purslow, P.P., Kadler, K.E., Bechet, D. and Wess, T.J. (2012).Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture. J Appl Physiol. 113, 878-88. PubMed
Harrop, C.A., Thornton, D.J., McGucking, M.A. (2012). Detecting, visualising, and quantifying mucins. Methods Mol Biol 842, 49-66. PubMed
Herchenhan A, Kalson NS, Holmes DF, Hill P, Kadler KE, Margetts L. (2012). Tenocyte contraction induces crimp formation in tendon-like tissue.Biomech Model Mechanobiol. 11, 449-59. PubMed
Hasnain, S., Grencis, R.K. and Thornton, D.J.(2012). Serine protease(s) secreted by thenematode Trichuris muris degrade the mucus barrier. PLoS Neg. Trop. Dis ePub 11 October.
Hull, R., Johnson, P.Y., Braun, K.R., Day, A.J. & Wight, T.N. (2012). Hyaluronan and hyaluronan-binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types. J. Histochem. Cytochem. 60, 749-760.
Jackson, G., Briggs, M.D., and the European Skeletal Dysplasia Network. (2012). Pseudoachondroplasia and multiple epiphyseal dysplasia; a 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution. Human Mutation 33, 144-57. PubMed
Kimber, I., Travis, M.A., Martin, S.F. and Dearman, R.J. (2012). Immunoregulation of skin sensitization and regulatory T cells. Contact Dermatitis, 67, 179-183. PubMed
Kung, L., Rajpar, M.H., Briggs, M.D. and Boot-Handford, R.P. (2012) Hypertrophic Chondrocytes Have a Limited Capacity to Cope with Increases in Endoplasmic Reticulum Stress Without Triggering the Unfolded Protein Response. J Histochem Cytochem. Epub ahead of print PubMed
Jeanes, A.I., Wang, P., Moreno-Layseca, P., Paul, N., Cheung, J., Tsang, R., Akhtar, N., Foster, F.M., Brennan, K. and Streuli, C.H. (2012). Specific β-containing integrins exert differential control on proliferation and 2D collective cell migration in mammary epithelial cells. J. Biol. Chem. 287, 24103-12. PubMed
Keenan, T.D.L., Clark, S.J., Unwin, R., Ridge, L.A., Day, A.J. and Bishop, P.N. (2012). Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid and sclera. Invest. Ophthalmol. Vis. Sci., 53, 7528-7538. PubMed
Leali, D., Inforzato, A., Ronca, R. Bianchi, R., Belleri, M., Coltrini, D., Di Salle, E., Sironi, M., Danilo, G., Bottazzi, B., Garlanda, C., Day, A.J., Presta, M. (2012). Long pentraxin 3/TSG-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis. Arteriosclerosis Thrombosis & Vascular Biology 32, 696-703. PubMed
Le Goff, M.M., Sutton, M.J., Slevin, M., Latif, A., Humphries, M.J. and Bishop, P.N. (2012). Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness. J. Biol. Chem. 287, 28027-28036. PubMed
Long, D.A. and Lennon, R. (2012). The renal archaeologist: digging for clues in archived tissues to understand diabetic kidney disease. Nephrol Dial Transplant. 27, 1693-5. PubMed
Lu, P., Weaver, V.M., Werb, Z. (2012). The extracellular matrix: A dynamic niche in cancer progression. J Cell Biol. 196, 395-406. PubMed
Mathew, S., Lu, Z., Palamuttam, R.J., Mernaugh, G., Hadziselimovic, A., Chen, J., Bulus, N., Gewin, L.S., Voehler, M., Meves, A., Ballestrem, C., Fässler, R., Pozzi, A., Sanders, C.R. and Zent, R. (2012). β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins. Mol Cell Biol. 32, 4080-91. PubMed
Mould, A.P. (2012). Analyzing integrin-dependent adhesion. Curr Protoc Cell Biol. Chapter 9: Unit 9.4. PubMed
Muller PA, Trinidad AG, Timpson P, Morton JP, Zanivan S, van den Berghe PV, Nixon C, Karim SA,Caswell PT, Noll JE, Coffill CR, Lane DP, Sansom OJ, Neilsen PM, Norman JC, Vousden KH. (2012). Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene. doi: 10.1038/onc.2012.148. PubMed
Rainero, E., Caswell, P.T., Muller, P.A., Grindlay, J., McCaffrey, M.W., Zhang, Q., Wakelam, M.J., Vousden, K.H., Graziani, A., Norman, J.C. (2012). Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration. J Cell Biol. 196, 277-95. PubMed
Rashid, S.T., Humphries, J.D., Byron, A., Dhar, A., Askari, J.A., Selley, J.N., Knight, D., Goldin, R.D., Thursz, M., Humphries, M.J. (2012). Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver. J Proteome Res11, 4052-64.
Robinson, C.V., Elkins, M.R., Bialkowski, K., Thornton, D.J. and Kertesz, M.A. (2012). Desulphurisation of mucin by Pseudomonas aeruginosa - influence of sulphate in the cystic fibrosis lung. J Med Microbiol. Epub ahead of print. PubMed
Rousseau, K., Swallow, D.M. (2012). Mucin methods: genes encoding mucins and their genetic variation with a focus on gel-forming mucins. Methods Mol Biol 842, 1-26. PubMed
Sarrab, R.M., Lennon, R., Ni, L., Wherlock, M.D., Welsh, G.I. and Saleem, M.S. (2011). Establishment of conditionally immortalised human glomerular mesangial cells in culture, with unique migratory properties. Am J Physiol Renal Physiol. 301, F1131-8. PubMed
Seror, J., Merkher, Y., Kampf, N., Collinson, L., Day, A.J., Maroudas, A. and Klein, J. (2012). Normal and shear interactions between hyaluronna-aggrecan complexes mimicking possible boundary lubricants in articular cartilage in synovial joints. Biomacromolecules 13, 3823-3832. PubMed
Suleman, F., Gualeni, B., Gregson, H.J., Leighton, M.P., Piróg, K.A., Edwards, S., Holden, P., Boot-Handford R.P. and Briggs, M.D. (2012). A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia. Hum Mutat. 33, 218-31. PubMed
Swingler, T.E., Wheeler, G., Carmont, V., Elliott, H.R., Barter, M.J., Abu-Elmagd, M., Donell, S.T., Boot-Handford, R.P., Hajihosseini, M.K., Münsterberg, A., Dalmay, T., Young, D.A. and Clark, I.M. (2012). The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum. 64, 1909-19. PubMed
Tonge, D.A., de Burgh, H.T., Docherty, R., Humphries, M.J., Craig, S.E. and Pizzey, J. (2012) Fibronectin supports neurite outgrowth and axonal regeneration of adult brain neurons in vitro. Brain Res. 1453, 8-16. PubMed
Williams, A., Christley, R.M., McKane, S.A., Roberts, V.L.H., Clegg, P.D. and Williams, N.J. (2012). Antimicrobial resistance changes in enteric Escherichia coli of horses during hospitalisation: Resistance profiling of isolates. The Veterinary Journal Sep 8. [Epub ahead of print].
Williams, A., Peachey, L.E. and Christley, R.M. (2012). Assessment of a point-of-care test for measurement of blood triglyceride levels for rapid detection of equid hypertriglyceridaemia. Equine Veterinary Education24, 520-8.
Woolner, S. and Papalopulu, N. (2012). Spindle position in symmetric cell division during epiboly is controlled by opposing and dynamic apicobasal forces. Developmental Cell. 22, 775-787. PubMed
Worthington, J.J., Fenton, T.M., Czajkowska, B.I., Klementowicz, J.E. and Travis, M.A. (2012). Regulation of TGFβ in the immune system: An emerging role for integrins and dendritic cells. Immunobiology. Epub ahead of print PubMed
Yeo, G.C., Baldock, C., Tuukkanen, A., Roessle, M., Dyksterhuis, L.B., Wise, S.G., Matthews, J., Mithieux, S.M., Weiss, A.S. (2012). The tropoelastin bridge region positions the cell-interactive C-terminus and contributes to elastic fiber assembly. Proc Natl Acad Sci U S A., 109, 2878-2883. PubMed
Zhang, S., He, H., Day, A.J. & Tsang, S.C.G. (2012). Constitutive expression of IaI family proteins by human amniotic membrane epitherlial and stromal cells supporting formation of the HC-HA complex. J. Biol. Chem. 287, 12433-44. PubMed
Zhao, X., Akhtar, R., Nijenhuis, N., Wilkinson, S.J., Murphy, L., Ballestrem, C., Sherratt, M.J., Watson, R.E. and Derby, B. (2012). IEEE Trans Ultrason Ferroelectr Freq Control. 59, 610-20. PubMed