Publications

Research publications

Principal investigators in the Wellcome Trust Centre for Cell-Matix Research publish around 70 research articles annually. Publications for 2010 are listed below.  Other years' publications are available via the links on the left-hand menu.

Byron, A., Morgan, M. R., and Humphries, M. J. (2010) Adhesion signalling complexes, Curr. Biol 20, R1063-1067 PubMed link.

Lindsay, J., Esposti, M. D., and Gilmore, A. P. (2010) Bcl-2 proteins and mitochondria-Specificity in membrane targeting for death, Biochim Biophys Acta PubMed link.

Welsh, G. I., Hale, L. J., Eremina, V., Jeansson, M., Maezawa, Y., Lennon, R., Pons, D. A., Owen, R. J., Satchell, S. C., Miles, M. J., Caunt, C. J., McArdle, C. A., Pavenstädt, H., Tavaré, J. M., Herzenberg, A. M., Kahn, C. R., Mathieson, P. W., Quaggin, S. E., Saleem, M. A., and Coward, R. J. M. (2010) Insulin signaling to the glomerular podocyte is critical for normal kidney function, Cell Metab 12, 329-340 PubMed link.

Kapacee, Z., Yeung, C. C., Lu, Y., Crabtree, D., Holmes, D. F., and Kadler, K. E. (2010) Synthesis of embryonic tendon-like tissue by human marrow stromal/mesenchymal stem cells requires a three-dimensional environment and transforming growth factor β3, Matrix Biol 29, 668-677 PubMed link.

Eva, R., Dassie, E., Caswell, P. T., Dick, G., ffrench-Constant, C., Norman, J. C., and Fawcett, J. W. (2010) Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells, J. Neurosci 30, 11654-11669 PubMed link.

Shenoy, M., Plant, N. D., Lewis, M. A., Bradbury, M. G., Lennon, R., and Webb, N. J. A. (2010) Intravenous methylprednisolone in idiopathic childhood nephrotic syndrome, Pediatr. Nephrol 25, 899-903 PubMed link.

Worth, D. C., Hodivala-Dilke, K., Robinson, S. D., King, S. J., Morton, P. E., Gertler, F. B., Humphries, M. J., and Parsons, M. (2010) Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration, J Cell Biol 189, 369-83 PubMed link.

Wong, J. K., Alyouha, S., Kadler, K. E., Ferguson, M. W., and McGrouther, D. A. (2010) The cell biology of suturing tendons, Matrix Biol PubMed link.

Wolny, P. M., Banerji, S., Gounou, C., Brisson, A. R., Day, A. J., Jackson, D. G., and Richter, R. P. (2010) Analysis of CD44-hyaluronan interactions in an artificial membrane system: insights into the distinct binding properties of high and low molecular weight hyaluronan, J Biol Chem PubMed link.

Wellbrock, C., and Hurlstone, A. (2010) BRAF as therapeutic target in melanoma, Biochem Pharmacol PubMed link.

Tooley, L. D., Zamurs, L. K., Beecher, N., Baker, N. L., Peat, R. A., Adams, N. E., Bateman, J. F., North, K. N., Baldock, C., and Lamande, S. R. (2010) Collagen VI microfibril formation is abolished by an α2(VI) von Willebrand factor A-domain mutation in a patient with Ullrich congenital muscular dystrophy, J Biol Chem PubMed link.

Tan, K., McGrouther, D., Day, A., Milner, C., and Bayat, A. (2010) Characterization of hyaluronan and TSG-6 in skin scarring: differential distribution in keloid scars, normal scars and unscarred skin, J Eur Acad Dermatol Venereol PubMed link.

Summers, L., Kangwantas, K., Nguyen, L., Kielty, C., and Pinteaux, E. (2010) Adhesion to the extracellular matrix is required for interleukin-1 beta actions leading to reactive phenotype in rat astrocytes, Mol Cell Neurosci PubMed link.

Scott, J. L., Gabrielides, C., Davidson, R. K., Swingler, T. E., Clark, I. M., Wallis, G. A., Boot-Handford, R. P., Kirkwood, T. B., Talyor, R. W., and Young, D. A. (2010) Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease, Ann Rheum Dis PubMed link.

Rooney, C., White, G., Nazgiewicz, A., Woodcock, S. A., Anderson, K. I., Ballestrem, C., and Malliri, A. (2010) The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly, EMBO Rep 11, 292-8 PubMed link.

Rennalls, L. P., Seidl, T., Larkin, J. M., Wellbrock, C., Gore, M. E., Eisen, T., and Bruno, L. (2010) The melanocortin receptor agonist NDP-MSH impairs the allostimulatory function of dendritic cells, Immunology 129, 610-9 PubMed link.

Pirog, K. A., Jaka, O., Katakura, Y., Meadows, R. S., Kadler, K. E., Boot-Handford, R. P., and Briggs, M. D. (2010) A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia, Hum Mol Genet 19, 52-64 PubMed link.

Pirog, K. A., and Briggs, M. D. (2010) Skeletal dysplasias associated with mild myopathy-a clinical and molecular review, J Biomed Biotechnol 2010, 686457 PubMed link.

Owens, T. W., Foster, F. M., Valentijn, A., Gilmore, A. P., and Streuli, C. H. (2010) Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization, J Biol Chem 285, 1081-8 PubMed link.

Owens, T. W., Foster, F. M., Tanianis-Hughes, J., Cheung, J. Y., Brackenbury, L., and Streuli, C. H. (2010) Analysis of inhibitor of apoptosis protein family expression during mammary gland development, BMC Dev Biol 10, 71 PubMed link.

Oldershaw, R. A., and Hardingham, T. E. (2010) Notch signaling during chondrogenesis of human bone marrow stem cells, Bone 46, 286-293 PubMed link.

Nundlall, S., Rajpar, M. H., Bell, P. A., Clowes, C., Zeeff, L. A., Gardner, B., Thornton, D. J., Boot-Handford, R. P., and Briggs, M. D. (2010) An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia, Cell Stress Chaperones PubMed link.

Muschler, J., and Streuli, C. H. (2010) Cell-Matrix Interactions in Mammary Gland Development and Breast Cancer, Cold Spring Harb Perspect Biol PubMed link.

Melton, A. C., Bailey-Bucktrout, S. L., Travis, M. A., Fife, B. T., Bluestone, J. A., and Sheppard, D. (2010) Expression of alphavbeta8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice, J Clin Invest 120, 4436-44 PubMed link.

Massam-Wu, T., Chiu, M., Choudhury, R., Chaudhry, S. S., Baldwin, A. K., McGovern, A., Baldock, C., Shuttleworth, C. A., and Kielty, C. M. (2010) Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta, J Cell Sci 123, 3006-18 PubMed link.

Mariko, B., Ghandour, Z., Raveaud, S., Quentin, M., Usson, Y., Verdetti, J., Huber, P., Kielty, C., and Faury, G. (2010) Microfibrils and fibrillin-1 induce integrin-mediated signaling, proliferation and migration in human endothelial cells, Am J Physiol Cell Physiol PubMed link.

Macdonald, P. R., Lustig, A., Steinmetz, M. O., and Kammerer, R. A. (2010) Laminin chain assembly is regulated by specific coiled-coil interactions, J Struct Biol PubMed link.

Lone, M., Kungl, T., Koper, A., Bottenberg, W., Kammerer, R., Klein, M., Sweeney, S. T., Auburn, R. P., O'Kane, C. J., and Prokop, A. (2010) The nuclear protein Waharan is required for endosomal-lysosomal trafficking in Drosophila, J Cell Sci PubMed link.

Kalson, N. S., Holmes, D. F., Kapacee, Z., Otermin, I., Liu, Y., Ennos, R. A., and Kadler, K. E. (2010) An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery, Matrix Biol PubMed link.

Jowitt, T. A., Murdoch, A. D., Baldock, C., Berry, R., Day, J. M., and Hardingham, T. E. (2010) Order within disorder: Aggrecan chondroitin sulphate-attachment region provides new structural insights into protein sequences classified as disordered, Proteins PubMed link.

Jackson, G. C., Marcus-Soekarman, D., Stolte-Dijkstra, I., Verrips, A., Taylor, J. A., and Briggs, M. D. (2010) Type IX collagen gene mutations can result in multiple epiphyseal dysplasia that is associated with osteochondritis dissecans and a mild myopathy, Am J Med Genet A 152A, 863-9 PubMed link.

Inforzato, A., Baldock, C., Jowitt, T. A., Holmes, D. F., Lindstedt, R., Marcellini, M., Rivieccio, V., Briggs, D. C., Kadler, K. E., Verdoliva, A., Bottazzi, B., Mantovani, A., Salvatori, G., and Day, A. J. (2010) The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2, J Biol Chem PubMed link.

Holmes, D. F., Tait, A., Hodson, N. W., Sherratt, M. J., and Kadler, K. E. (2010) Growth of collagen fibril seeds from embryonic tendon: fractured fibril ends nucleate new tip growth, J Mol Biol 399, 9-16 PubMed link.

Hasnain, S. Z., Wang, H., Ghia, J. E., Haq, N., Deng, Y., Velcich, A., Grencis, R. K., Thornton, D. J., and Khan, W. I. (2010) Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection, Gastroenterology PubMed link.

Harrison, H., Farnie, G., Howell, S. J., Rock, R. E., Stylianou, S., Brennan, K. R., Bundred, N. J., and Clarke, R. B. (2010) Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor, Cancer Res 70, 709-18 PubMed link.

Hardingham, T. E. (2010) Fell-Muir lecture: cartilage 2010 - the known unknowns, Int J Exp Pathol 91, 203-9 PubMed link.

Goldyn, A. M., Kaiser, P., Spatz, J. P., Ballestrem, C., and Kemkemer, R. (2010) The kinetics of force-induced cell reorganization depend on microtubules and actin, Cytoskeleton PubMed link.

Fresquet, M., Jowitt, T. A., Stephen, L. A., Ylostalo, J., and Briggs, M. D. (2010) Matrilin-1 A-domains: structural and functional investigations reveal insights into their role in cartilage ecm assembly, J Biol Chem PubMed link.

Faye, C., Inforzato, A., Bignon, M., Hartmann, D. J., Muller, L., Ballut, L., Olsen, B. R., Day, A. J., and Ricard-Blum, S. (2010) Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells, Biochem J PubMed link.

Daly, S. B., Urquhart, J. E., Hilton, E., McKenzie, E. A., Kammerer, R. A., Lewis, M., Kerr, B., Stuart, H., Donnai, D., Long, D. A., Burgu, B., Aydogdu, O., Derbent, M., Garcia-Minaur, S., Reardon, W., Gener, B., Shalev, S., Smith, R., Woolf, A. S., Black, G. C., and Newman, W. G. (2010) Mutations in HPSE2 cause urofacial syndrome, Am J Hum Genet 86, 963-9 PubMed link.

Clark, S. J., Perveen, R., Hakobyan, S., Morgan, B. P., Sim, R. B., Bishop, P. N., and Day, A. J. (2010) Impaired binding of the AMD-associated complement factor H 402H allotype to Bruch's membrane in human retina, J Biol Chem PubMed link.

Carisey, A., and Ballestrem, C. (2010) Vinculin, an adapter protein in control of cell adhesion signalling, Eur J Cell Biol PubMed link.

Canty-Laird, E., Carre, G. A., Mandon-Pepin, B., Kadler, K. E., and Fabre, S. (2010) First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles, Biol Reprod 83, 138-46 PubMed link.

Boot-Handford, R. P., and Briggs, M. D. (2010) The unfolded protein response and its relevance to connective tissue diseases, Cell Tissue Res 339, 197-211 PubMed link.

Berry, R., Jowitt, T. A., Garrigue-Antar, L., Kadler, K. E., and Baldock, C. (2010) Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase, FEBS Lett 584, 657-661 PubMed link.

Bella, J. (2010) A new method for describing the helical conformation of collagen: Dependence of the triple helical twist on amino acid sequence, J Struct Biol PubMed link.

Bayer, M. L., Yeung, C. Y., Kadler, K. E., Qvortrup, K., Baar, K., Svensson, R. B., Magnusson, S. P., Krogsgaard, M., Koch, M., and Kjaer, M. (2010) The initiation of embryonic-like collagen fibrillogenesis by adult human tendon fibroblasts when cultured under tension, Biomaterials 31, 4889-97 PubMed link.

Ball, S. G., Shuttleworth, C. A., and Kielty, C. M. (2010) Platelet-derived growth factor receptors regulate mesenchymal stem cell fate: implications for neovascularization, Expert Opin Biol Ther 10, 57-71 PubMed link.

Ball, S. G., Bayley, C., Shuttleworth, C. A., and Kielty, C. M. (2010) Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells, Biochem J 427, 29-40 PubMed link.

Askari, J. A., Tynan, C. J., Webb, S. E., Martin-Fernandez, M. L., Ballestrem, C., and Humphries, M. J. (2010) Focal adhesions are sites of integrin extension, J Cell Biol 188, 891-903 PubMed link.

Arkwright, P. D., Luchetti, F., Tour, J., Roberts, C., Ayub, R., Morales, A. P., Rodriguez, J. J., Gilmore, A., Canonico, B., Papa, S., and Esposti, M. D. (2010) Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes, Cell Res 20, 72-88 PubMed link.