Centre News

News

2013
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2012
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2011
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2010
- 17 December
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- 8 October
- 24 September
- 10 September
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15 JANUARY 2010

Congratulations to...

Toby Starborg, Hui Lu, David Holmes & Karl Kadler
Their paper (T.Starborg, Y. Lu, A. Holmes, K.E. Kadler: Electron microscope 3D reconstruction of branched collagen fibrils in vivo), published in 2009 has been selected as one of the two winners of the MESSNER PRICE 2010. The prize is given to the corresponding authors of the best papers during 2009 in the journal, Scand J Med Science Sports, with the primary purpose of supporting high quality research on a sound ethical basis in the wide field of Sports Medicine.

Invited Seminars

Tony Day
Ocular Surface Center, Miami, USA, in Dec 09. Title: TSG-6 and Inter-alpha-Inhibitor interactions in inflammation and ovulation

Mark Morgan
Actin 2009 meeting, Bristol, December 2009. Title: Syndecan-4 phosphorylation: A central regulator integrin trafficking

Charles Streuli
Molecular Biotechnology Centre, Turin. Hosted by Paola deFilippi on 12 Jan 10. Title: The essential role of integrins in controlling development and epithelial function in the mammary gland

Papers accepted or published

Berry, R., Jowitt, T.A., Garrigue-Antar, L., Kadler, K.E., and Baldock, C. (2009). Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase. FEBS Lett. [Epub ahead of print] PubMed PMID: 20043912.

Gail C. Jackson, Dominique Marcus-Soekarman, Irene Stolte-Dijkstra, Aad Verrips, Jacqueline A. Taylor and Michael D. Briggs (2010). Type IX Collagen Gene Mutations can result in Multiple Epiphyseal Dysplasia that is associated with Osteochondritis Dissecans and a Mild Myopathy. American Journal of Medical Genetics

Jones, R.P., Ridley, C., Jowitt, T.A., Wang, M.C., Howard, M., Bobola, N., Wang, T., Bishop, P.N., Kielty, C.M., Baldock, C., Lotery, A., and Trump, D. (2010). Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa. Invest Ophthalmol Vis Sci. [Epub ahead of print] PubMed PMID: 20007835.

Grants awarded

Andrew Gilmore
CRUK project grant entitled: The role of the BH3-only protein Bid in mitosis and paclitaxel resistance. Three years commencing April '10, with Dr. Jennefer Lindsay.

Congratulations to Andrew Gilmore, for helping to secure a EMBO Long Term Fellowship for Dr. Barbara Schellenberg, who will be in Andrew's lab for two years from May '10. The grant is on Reversible mitochondrial targeting of Bax during anoikis, and it will examine the removal of pro-apoptotic Bax from mitochondria by the proteasome following activation of ECM signalling. Barbara is from the Institute of Plant Biology, University of Zurich, Switzerland, where she has worked on novel proteasome inhibitors.

Conference talks

Paul Bishop
Macular Vision Research Foundation, Washington DC, USA (Nov 09)
Macula in Paris, Paris (15 Jan 10)

Tony Day
Invited plenary lecture at 20^th International Symposium on Glycoconjugates, San Juan, Puerto Rico, USA. (Dec 09) Title: Glycosaminoglycan-protein interactions in innate immunity and inflammation

Papers accepted or published

Harrison, H., Farnie, G., Howell, S.J., Rock, R.E., Stylianou, S., Brennan, K.R., Bundred, N.J., and Clarke, R.B. (2010). Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor. Cancer Res. [Epub ahead of print] PubMed PMID: 20068161.

Marson, A., Robinson, D.E., Brookes, P.N., Mulloy, B., Wiles, M., Clark, S.J., Fielder, H.L., Collinson, L.J., Cain, S.A., Kielty, C.M., McArthur, S., Buttle, D.J., Short, R.D., Whittle, J.D., and Day, A.J. (2009). Development of a microtiter plate-based glycosaminoglycan array for the investigation of glycosaminoglycan-protein interactions. Glycobiology. 19: 1537-46.

New Staff

We'd like to welcome:
Claire Hartley, who comes as a post doc to the Briggs Lab from Paul Bishop’s lab where she worked on the characterisation of opticin as an anti-tumour therapeutic.

Amrit Ramakrishnan, who is a new MPhil student, also in the Briggs Lab who has come from the University of Sheffield.

Poster presentations

Julia Cheung (with Charles Streuli)
ASCB Meeting, San Diego, December 2009. Title: The role of Beta-1 Integrin in Mammary Gland Ductal Morphogenesis

Hellyeh Hamidi (with Mark Morgan, Mark Bass and Martin Humphries)
Actin 2009 meeting in Bristol in December. Title: Regulation of Syndecan-4 signalling by differential phosphorylation

Tom Owens (with Andrew Gilmore)
ASCB Meeting, San Diego, December 2009. Title: Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK

Papers accepted or published

Owens, T.W., Foster, F.M., Valentijn, A., Gilmore, A.P., and Streuli, C.H. (2010). Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization. J Biol Chem. 285: 1081-8.

Pattwell, D.M., Sheridan, C.M., Le Goff, M., Bishop, P.N., and Hiscott, P. (2009). Localisation of opticin in human proliferative retinal disease. Exp Eye Res. [Epub ahead of print] PubMed PMID: 20036236.

Sanchez-Soriano, N., Goncalves-Pimentel, C., Beaven, R., Haessler, U., Ofner-Ziegenfuss, L., Ballestrem, C., and Prokop, A. (2010). Drosophila growth cones: A genetically tractable platform for the analysis of axonal growth dynamics. Dev Neurobiol. 70: 58-71.