News

Papers published

Clark, S.J., Keenan, T., Fielder, H.L., Collinson, L.J., Holley, R.J., Merry, C.L., van Kuppevelt, T.H., Day, A.J. & Bishop, P.N. (2011).Mapping the differential distribution of glycosaminoglycans in the adult human retina, choroid and sclera. Invest. Ophthalmol. Vis. Sci. 52, 6511-6521. PubMed link

Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Kerkhof HJ, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Loughlin J, McCaskie A, Ollier WE, Ralston SH, Spector TD, Wallis GA, Wilkinson JM, Aslam N, Birell F, Carluke I, Joseph J, Rai A, Reed M, Walker K; arcOGEN Consortium, Doherty SA, Jonsdottir I, Maciewicz RA, Muir KR, Metspalu A, Rivadeneira F, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JB, Zhang W, Valdes AM, Doherty M, Zeggini E. (2011). A Variant in MCF2L Is Associated with Osteoarthritis. Am J Hum Genet. PubMed link

Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD; arcOGEN Consortium, Akune T, Arden NK, Carr A, Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom G, Gonzalez A, Halldorsson BV, Hammond CL, Hart DJ, Helgadottir H, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H, Kisand K, Kloppenburg M, Kujala UM, Lohmander LS, Loughlin J, Luyten FP, Mabuchi A, McCaskie A, Nakajima M, Nilsson PM, Nishida N, Ollier WE, Panoutsopoulou K, van de Putte T, Ralston SH, Rivadeneira F, Saarela J, Schulte-Merker S, Shi D, Slagboom PE, Sudo A, Tamm A, Tamm A, Thorleifsson G, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Yoshimura N, Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden AG, Felson DT, van Meurs JB, Stefansson K, Ioannidis JP, Spector TD; Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA). (2011). Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis. 70: 349-55. PubMed link

Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G, Beazley C, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Doherty M, McCaskie A, Ollier WE, Ralston SH, Spector TD, Valdes AM, Wallis GA, Wilkinson JM, Arden E, Battley K, Blackburn H, Blanco FJ, Bumpstead S, Cupples LA, Day-Williams AG, Dixon K, Doherty SA, Esko T, Evangelou E, Felson D, Gomez-Reino JJ, Gonzalez A, Gordon A, Gwilliam R, Halldorsson BV, Hauksson VB, Hofman A, Hunt SE, Ioannidis JP, Ingvarsson T, Jonsdottir I, Jonsson H, Keen R, Kerkhof HJ, Kloppenburg MG, Koller N, Lakenberg N, Lane NE, Lee AT, Metspalu A, Meulenbelt I, Nevitt MC, O'Neill F, Parimi N, Potter SC, Rego-Perez I, Riancho JA, Sherburn K, Slagboom PE, Stefansson K, Styrkarsdottir U, Sumillera M, Swift D, Thorsteinsdottir U, Tsezou A, Uitterlinden AG, van Meurs JB, Watkins B, Wheeler M, Mitchell S, Zhu Y, Zmuda JM; arcOGEN Consortium, Zeggini E, Loughlin J. (2011). Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Ann Rheum Dis. 7: 864-7. PubMed link

Southam L, Panoutsopoulou K, Rayner NW, Chapman K, Durrant C, Ferreira T, Arden N, Carr A, Deloukas P, Doherty M, Loughlin J, McCaskie A, Ollier WE, Ralston S, Spector TD, Valdes AM, Wallis GA, Wilkinson JM; arcOGEN consortium, Marchini J, Zeggini E. (2011). The effect of genome-wide association scan quality control on imputation outcome for common variants. Eur J Hum Genet. 19: 610-4. PubMed link

Other news

Tim Hardingham has been invited to be a member of the NC3R Grant Assessment Panel for a further 3 years (2012-2014).

Rebecca (Becky) Taylor We’d like to welcome Becky to the Centre. She has joined the Canfield and Day labs as a BHF-funded PhD student to work on a project entitled: ‘Elucidating the role of TSG-6 in vascular calcification’.  Becky is on the 4 year PhD programme funded by the BHF and previously undertook one of her rotation projects in the Canfield lab.

Papers accepted

Bass, M.D., Williamson, R.C., Humphries, J.D., Byron, A., Morgan, M.R., Martin P. and Humphries, M.J. (2011). A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Dev. Cell in press.

Broadie, K., Baumgartner, S., and Prokop, A. (2011). Extracellular matrix and its receptors in Drosophila neural development. Dev Neurobiol, in press.

Jackson, G., Briggs, M.D., and the European Skeletal Dysplasia Network. (2011). Pseudoachondroplasia and multiple epiphyseal dysplasia; a 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution. Human Mutation in press.

Liu, Y., Wang,T., Yan, J., Jiagbogu, N., Heideman, D.A.M., Canfield, A.E., Alexander, M.Y. (2011).HGF/c-Met Signaling Promotes Notch3 Activation and Human Vascular Smooth Muscle Cell Osteogenic Differentiation In Vitro. Atherosclerosis in press.

Rantala, J.K., Pouwels, J., Pellinen, T., Veltel, S., Laasola, P., Potter, C.S., Duffy, T., Sundberg, J.P., Kallioniemi, O., Askari, J.A., Humphries, M., Parsons, M., Salmi, M. and Ivaska, J. (2011). Sharpin is an endogenous inhibitor of beta1-integrin activation. Nature Cell Biol. in press.

Reichardt L, Prokop A. (2011). The role of extracellular matrix in nervous system development and maintenance (editorial). Dev Neurobiol. in press.

Seror, J., Merkher, Y., Kampf, N., Collinson, L.J., Day, A.J., Maroudas, A. & Klein, J. (2011). Articular cartilage proteoglycans as boundary lubricants. I) Structure and frictional interaction of surface-attached hyaluronan-aggrecan complexes. Biomacromolecules J., in press.

Wang P, Ballestrem C, Streuli CH. (2011). The C’-terminus of talin links integrins to cell cycle progression. Journal of Cell Biology in press.

Invited seminars

Keith Brennan

Cancer Institute, University of Mississippi Medical Centre, Jackson, Mississippi, 29 August. Using Development to understand Breast Cancer

Adam Byron

Complexity in the Life Sciences: Combining Biological and Computational Approaches, University of Manchester, 6 September. Analysing the complexity of cell adhesion: A proteomic approach

Mark Morgan

North of England Cell Biology (NECB) Forum, Sheffield University, 9 September. Syndecan-4 phosphorylation: a critical control point regulating integrin recycling and cell migration

Congratulations to Mark for winning the NECB Investigator Award.

Dave Thornton

Glenfield Hospital, University of Leicester, 31 August.  Mucus in health and disease

Adele Williams

British Equine Veterinary Association (BEVA) congress, Liverpool, 7-9 September. Increase of Muc5ac and Muc5b glycoprotein in equine airway mucus accumulation and characterization of Muc5ac and Muc5b from primary equine airway epithelial cells in culture. Validation of a point-of-care test for measurement of equine blood and serum triglyceride levels.

Poster presentations

Simon Clark

XIIIth European meeting on Complement in Human Disease, Leiden, The Netherlands, 21-24 August. The CCP6-8 and CCP19-20 ‘heparin’-binding regions of complement factor H have different and tissue-specific glycosaminoglycan-binding properties

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Talks

Nasreen Akhtar An integrin signalling network orients epithelial polarity and lumen formation via endocytosis of apical proteins

Alex Carisey Tension-dependent activation of vinculin drives focal adhesion formation and disassembly

Simon ClarkThe two polyanion-binding regions of complement factor H have different GAG binding propertires: implications for tissue specific immune regulation.

Guillaume Jacquement Recruitment of filamin-A and IQGAP1 to active integrins regulates Rac1 activity

Cay Kielty Keynote lecture

Mark Morgan Syndecan-4 Phosphorylation: a critical control point regulating integrin recycling and cell migration

Helen Troilo The role of chordin in regulating bone morphogenetic protein signalling

Scott Walker Transformation of mammary epithelial acini by focal adhesion kinase (FAK)

Posters

Nasreen Akhtar An integrin signalling network orients epithelial polarity and lumen formation via endocytosis of apical proteins

Alex Carisey Tension-dependant activation of vinculin drives focal adhesion formation and disassembly

Julia Cheung The role of β1-integrin in mammary gland ductal morphogenesis

Simon Clark The two polyanion-binding regions of complement factor H have different GAG binding properties: implications for tissue specific immune regulation

Gareth Hyde Gas6/Axl suppresses both osteogenic differentiation and apoptosis of vascular smooth muscle cells during phosphate-induced mineralisation

Guillaume Jacquemet Recruitment of filamin-A and IQGAP1 to active integrins regulates Rac1 activity

Rachel Lennon Novel glomerular matrix components identified by mass spectrometry based  proteomics

Jen Lindsay The pro-apoptotic protein Bid is phosphorylated during mitosis and regulates apoptosis in response to anti-mitotic drugs

Paulina Moreno-Layseca How integrin-mediated adhesion controls cell proliferation in breast epithelia

Mark Morgan Syndecan-4 Phosphorylation: a critical control point regulating integrin recycling and cell migration

Nikki Paul Proteomic analysis of signalling by adhesion and growth factor receptors in mammary epithelial cells

Andreas Prokop Understanding microtubule regulation during nervous system development

Barbara Schellenberg Does Mcl-1 regulate apoptosis commitment in epithelial cells?

Helen Troilo The role of chordin in regulating bone morphogenetic protein signalling

Scott Walker Transformation of Mammary Epithelial Acini by Focal Adhesion Kinase

Pengbo Wang The C’-terminus of talin links integrin signaling to cell cycle

Congratulations to...

Guillaume Jacquemet for winning the poster prize and Nasreen Akhtar and Alex Carisey for being awarded the best talk prizes in their sessions.

And a big thank you to Gareth Hyde and Helen Troilo for their fantastic organisation of the whole event

Public engagement

The Brennan lab had a work experience student, Vivienne Stott Morrison, from Chorlton High School for a week over the summer.

Rebecca Taylor took part in ‘Meet the Physiologist’ at the Museum of Science and Industry on 3 September. The event aimed to inform and educate the public about physiology with the aid of a variety of interactive mini experiments.