16 Jun 2017 - Centre news

Copyright © Wellcome trust centre for Cell-Matrix Research Congratulations to Christoph Ballestrem, Martin Humphries and Mark Travis on their successful BBSRC grant applications!  The Centre held it’s summer symposium on 15 June and a big thank you to all the postdocs and students who responded to the call for abstracts.  A small team of Group Leaders selected 6 talks that represent research across the Centre.  The quality of the abstracts was superb and it was a difficult task to select just 6 (see photo, from L-R: Hamish Gilbert, Richa Garva, Charlene Jouy, Joe Hetmanski, Aoife Kelly, Jack Williams).

Grants awarded

Christoph Ballestrem and Martin Humphries (with David Garrod), BBSRC, October 2017 - September 2020. Determination of the mechanisms of desmosome loss during EMT

Mark Travis (with Dan Davis and Philip Woodman), BBRSC, October 2017 - September 2020. Determining a novel pathway that controls TGF-beta activation in the immune system

Papers published

Gross, O., Kashtan, C.E., Rheault, M.N., Flinter, F., Savige, J., Miner, J.H., Torra, R., Ars, E., Deltas, C., Savva, I., Perin, L., Rennerei, A., Ariani, F., Mari, M., Baigent, C., Judge, P., Knebelman, B., Heidet, L., Lagas, S., Blatt, D., Ding, D., Zhang, Y., Gale, D.P., Prunotto, M., Xue, Y., Schachter, A.D., Morton, L.C.G., Blem, J., Huang, M., Liu, S., Vallee, S., Renault, D., Schifter, J., Skelding, J., Gear, S., Friede, T., Turner, A.N. and Lennon, R. (2017) Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome. Nephron Dial Transplant. 32, 916-924. PubMed

Kadler, K.E. (2017) Fell Muir Review: Collagen fibril formation in vitro and in vivo. Int J Exp Pathol. 98, 4-16. PubMed 

Minutti, C.M., Jackson-Jones, L.H., García-Fojeda, B., Knipper, J.A., Sutherland, T.E., Logan, N., Rinqvist, E., Guillamat-Prats, R., Ferenbach, D., Artigas, A., Stamme, C., Chroneos, Z.C., Zaiss, D.M., Casals*, C. and Allen*, J.E. Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver.  Science. 356, 1076-1080. *Corresponding authors. PubMed

Svensson, R.B., Herchenhan, A., Starborg, T., Larsen, M., Kadler, K.E., Qvortrup, K. and Magnusson, S.P. (2017) Evidence of structurally continuous collagen fibrils in tendon.  Acta Biomater. 50, 293-301. PubMed

Papers accepted

Atherton, P., Lausecker, F., Harrison, A. and Ballestrem, C. Low Intensity Pulsed Ultrasound (LIPUS) promotes cell motility through vinculin-controlled Rac1 GTPase activity. J Cell Sci. In press. Epub ahead of print

Tunnicliffe, R.B., Lockhart-Cairns, M.P., Levy, C., Mould, A.P., Jowitt, T.A., Sito, H., Baldock, C., Sandri-Goldin, R.M. and Golovanov, A.P. The herpes viral transcription factor ICP4 forms a novel DNA recognition complex. Nucleic Acids Res. In press. Epub ahead of print 

Conferences, invited seminars and meetings

Judi Allen, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, USA, 1 June. Tissue guardians during injury and infection: macrophages, type 2 cytokines & defence collagens

Crick Institute, London, 14 June. Protecting your tissues: Type 2 cytokines, macrophages and defense collagens

Clair Baldock, University of Oulu Mini-symposium on Future directions in ECM research relevant to fibrosis, 5 June. Structural studies of elastic tissues and extracellular regulation of TGFbeta signalling

Danish Cardiovascular Research Academy 2017 Summer Meeting, The Sandbjerg Estate, Denmark, 14 - 16 June. Structure and assembly of elastic fibre proteins tropoelastin and fibrillin

Christoph Ballestrem, European Cytoskeletal Forum (ECF 2017), Helsinki, Finland, 4-8 June. The role of talin and vinculin in connecting the cell-matrix adhesions to the cytoskeleton

Abby Cowley, Thornton lab, poster presentation, 40th European Cystic Fibrosis Conference, Seville, Spain, 7-10 June. A. fumigatus degrades the respiratory mucins MUC5B and MUC5AC. Congratulations to Abby for being awarded first prize in the ‘Microbiology/Antibiotics’ section

Karl Kadler, Cartilage Gordon Research Conference, Renaissance Tuscany Il Ciocco Resort, Italy, 2-7 April. Circadian Clock Regulation of the Secretory Pathway of Collagen

Jakub Lagan, Miller lab, selected abstract talk, EuroCMR, Prague, 25-27 May. USPIO CMR imaging suggests persistent myocardial inflammation in ischaemic cardiomyopathy. Congratulations to Jakub for being one of only six selected from over 250 submitted.

Qing-Jun Meng represented BSMB at the Annual Conference of the Chinese Society of Matrix Biology, Jishou, China, 6-10 June. Circadian clocks in health and disease of the articular cartilage

Cartilage Gordon Research Conference, Renaissance Tuscany Il Ciocco Resort, Italy, 2-7 April. The cartilage circadian clock in health and disease

Chris Miller, EuroCMR 2017, Prague, 25-27 May. CMR and transplantation

Martin Schwartz, Tissue Repair & Regeneration Gordon Research Conference, Colby-Sawyer College, New London, USA, 4-9 June. Matrix and mechanics in fibrosis

University of Sheffield, 25 May. Mechanical force and matrix remodeling in vascular health and disease

Charles Streuli, EMBO Conference on Cell polarity and membrane dynamics, Sant Feliu de Guixols, Spain, 5-8 June. Control of epithelial cell phenotype by cell-matrix interactions

6th FEBS Advance Lecture Course, Matrix Pathobiology, Signaling and Molecular Targets. Spetses, Greece, May 25th - 30th 2017

Ray Boot-Handford, tutorial, Collagens: Types and functions

Invited seminar, ER stress as a pathogenic factor in ECM diseases

Michel Dudek, poster presentation, Intervertebral disc possess and osmo- and mechano-sensitive circadian clock that temporally coordinates matrix homeostasis 

Jordan Wragg, selected talk, The impacts of ER stress associated chondrodysplasias on metabolism. Congratulations to Jordan for being awarded a best poster prize. 

Visitors to the Centre

The Centre hosted a visit from Baroness Eliza Manningham-Buller, Peter O’Donovan and Becky Sugden from the Wellcome, on 30 May. Many thanks to those who met the visiting team.

Jeremy Herrera, Bitterman Lab, University of Minnesota, 23 May. The role of decellularized ECM in fibrosis progression

Maria Marra (University of Galway) visited the Thornton lab from 22 May until 2 June 2017 to learn how to isolate mucin-like molecules from sea sponges.

Chun Yi Wen, Interdisciplinary Division of Biomedical Engineering, Hong Kong Polytechnic University visited the Meng lab on 31 May. 

Public Engagement

SAVE THE DATE: European Researchers Night Friday 29 September 2017

As part of our ongoing commitment to engaging with more adult audiences, we have previously supported (to great success) the annual event that is European Researchers Night. This is a Europe-wide public event dedicated to popular science and fun learning. It takes place each year on the last Friday in September. More than 30 countries and over 300 cities are involved.The event showcases what researchers really do for society, in interactive and engaging ways, and promote research careers to young adults.

Plans for this year's Science Uncovered at the Manchester Museum are well-underway so please save the date - Friday 29 September from 5pm until 10pm. The event includes music, cocktail bar, science café, stands and much more so is a really fun event to be a part of. 

Upcoming seminars

Carlos Minutti (University of Edinburgh) B.4208 Smith, 11am, 21 June. Defense collagens, type 2 cytokines and danger signals instruct macrophages to promote tissue repair

Christophe Guilluy (Institute for Advanced Biosciences, Grenoble, France) Michael Smith LT, 1pm, 23 June. Mechanical Control of Mitotic Progression via the Nuclear Envelope 

Nicholas Kurniawan (Department of Biomedical Engineering, Eindhoven University of Technology), 1.006 AV Hill, 11am, 27 June. Mechanobiology-driven in situ cardiovascular tissue engineering

Congratulations to…

Our excellent Core Facilities Managers, Tom Jowitt, Toby Starborg and Egor Zindy, have been formally underwritten by the Faculty which is a sign of their value and importance to the Faculty. 

A huge congratulations to Rachel Lennon and Qing-Jun Meng on their promotions to Professors. 

Anna Reid, a PhD student from the Miller lab, was awarded the Young Investigator of the Year award at the British Society of CMR, Manchester.

The Centre held it’s summer symposium on 15 June and a big thank you to all the postdocs and students who responded to the call for abstracts.  A small team of Group Leaders selected 6 talks that represent research across the Centre.  The quality of the abstracts was superb and it was a difficult task to select just 6 (see photo, from L-R: Hamish Gilbert, Richa Garva, Charlene Jouy, Joe Hetmanski, Aoife Kelly, Jack Williams).  

Other news

Ray Boot-Handford and Karl Kadler returned to Philadelphia after a 28 year absence to celebrate the 30th anniversary of the opening of the Jefferson Institute of Molecular Medicine at Jefferson University. A symposium focused on matrix biology, fibrosis and fibrotic diseases was held from 4-6 June to celebrate the founding of the Institute by Darwin Prockop.

Karl Kadler visited Salzburg from 16-17 May to attend the annual meeting of RUBICON, a Marie Curie EU Network focused on tendon pathologies and associated diseases. 

Dave Thornton has been appointed to the the Scientific Committee of the European Cystic Fibrosis (CF) Conference from 2017-2020. 

Dave has also been invited to join the European Science Foundation College of Expert Reviewers.