Editors: McGuckin, M.A., Thornton, D.J. (2012). Mucins: Methods and Protocols. Methods in Molecular Biology. Volume 842, 2012, DOI: 10.1007/978-1-61779-513-8.
Davies, J.R., Wickström, C., Thornton, D.J. (2012). Gel-forming and cell-associated mucins: preparation for structural and functional studies. Methods Mol Biol 842, 27-47. PubMed
Ferguson, J., Arozarena, I., Ehrhardt, M., Wellbrock, C. (2012). Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion. Oncogene doi: 10.1038/onc.2012.25. PubMed
Giacomini, M.M., Travis, M.A., Kudo, K., Sheppard, D. (2012). Epithelial cells utilize cortical actin/myosin to activate latent TGF-beta through integrin alphav beta6-dependent physical force. Exp. Cell Res Epub ahead of print. PubMed
Harrop, C.A., Thornton, D.J., McGucking, M.A. (2012). Detecting, visualising, and quantifying mucins. Methods Mol Biol 842, 49-66. PubMed
Leali, D., Inforzato, A., Ronca, R. Bianchi, R., Belleri, M., Coltrini, D., Di Salle, E., Sironi, M., Danilo, G., Bottazzi, B., Garlanda, C., Day, A.J., Presta, M. (2012). Long pentraxin 3/TSG-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis. Arteriosclerosis Thrombosis & Vascular Biology 32, 696-703. PubMed
Rousseau, K., Swallow, D.M. (2012). Mucin methods: genes encoding mucins and their genetic variation with a focus on gel-forming mucins. Methods Mol Biol 842, 1-26. PubMed
“The biology and pathology of Tau and its role in tauopathies II”, Robinson College, Cambridge, 8-9 January. Understanding Tau as a member of the complex machinery regulating the neuronal cytoskeleton
ECEIM (European College of Equine Internal Medicine) congress, Edinburgh, 1-4 February. Biochemical analysis of gel-forming mucins from respiratory secretions of horses with recurrent airway obstruction (RAO)
Congratulations to Adele for winning the prize for the best poster at this congress.
Andreas Prokop was a key organiser of the nEUroskeleton initiative of about 70 research groups Europe-wide, and of its first informal meeting in Brussels on the 27 January, including talks with EU officials. The initiative aims to promote the neuronal cytoskeleton as a funding area in the Horizon 2020 programme.
Luke Bonser for successfully defending his PhD thesis entitled ‘The assembly and processing of polymeric mucins’ supervised by Dave Thornton. Luke is moving to the US to take up a postdoc position in David Erle’s lab at UCSF.
Friday 3 February saw the Centre run its first event of this year's public programme: 'Genes to Phenotypes'. With our biggest turn out yet, 40 A'-level students from across Greater Manchester came along to work with Ray Boot-Handford, Louise Kung, Lorna Mullan and Becki Holley and learn about the Centre's research into short-limbed dwarfism. Students tried their hand at histology analysis, DNA sequencing and identifying phenotypes by measuring bone length. In the second half of the session, A'-level students met Douglas Dyer, Lisa Brackenbury, Rawshan Choudhury, Jen Thompson and Sam Roberts to learn more about their research in our ever-competitive 'Meet the Scientist' event. With votes tied in the first round between Doug and Sam, Lisa romped home in the second round to secure almost 60% of the votes! Many thanks to all those who volunteered their time to make this such a success. Friday 10 February sees the second round of Genes to Phenotypes...so watch this space!
Andreas Prokop hosted the University Board of Governers in the Fly Core Facility to explain the importance of using fruitflies in research. Michael Smith and Scott Walker presented posters at the same event. The feedback from the visitors was very positive.