Centre News

News

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Book published

Editors: McGuckin, M.A., Thornton, D.J. (2012). Mucins: Methods and Protocols. Methods in Molecular Biology. Volume 842, 2012, DOI: 10.1007/978-1-61779-513-8.

Papers published

Davies, J.R., Wickström, C., Thornton, D.J. (2012). Gel-forming and cell-associated mucins: preparation for structural and functional studies. Methods Mol Biol 842, 27-47. PubMed

Ferguson, J., Arozarena, I., Ehrhardt, M., Wellbrock, C. (2012). Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion. Oncogene doi: 10.1038/onc.2012.25. PubMed

Giacomini, M.M., Travis, M.A., Kudo, K., Sheppard, D. (2012). Epithelial cells utilize cortical actin/myosin to activate latent TGF-beta through integrin alphav beta6-dependent physical force. Exp. Cell Res Epub ahead of print. PubMed

Harrop, C.A., Thornton, D.J., McGucking, M.A. (2012). Detecting, visualising, and quantifying mucins. Methods Mol Biol 842, 49-66. PubMed

Leali, D., Inforzato, A., Ronca, R. Bianchi, R., Belleri, M., Coltrini, D., Di Salle, E., Sironi, M., Danilo, G., Bottazzi, B., Garlanda, C., Day, A.J., Presta, M. (2012). Long pentraxin 3/TSG-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis. Arteriosclerosis Thrombosis & Vascular Biology 32, 696-703. PubMed

Rousseau, K., Swallow, D.M. (2012). Mucin methods: genes encoding mucins and their genetic variation with a focus on gel-forming mucins. Methods Mol Biol 842, 1-26. PubMed

Invited talks

Mark Travis

'Biology of Cytokines' Keystone meeting, Keystone, CO, USA, 6-10 February. Expression of the TGF-beta-activating integrin alphav beta8 on dendritic cells: a crucial pathway for the induction of oral tolerance

Adele Williams

ECEIM (European College of Equine Internal Medicine) congress, Edinburgh, 1-4 February. Development of a cell culture system of cells collected by tracheal brushing to study mucus production in the equine airway epithelium

Poster presentations

Andreas Prokop

“The biology and pathology of Tau and its role in tauopathies II”, Robinson College, Cambridge, 8-9 January. Understanding Tau as a member of the complex machinery regulating the neuronal cytoskeleton

Adele Williams

ECEIM (European College of Equine Internal Medicine) congress, Edinburgh, 1-4 February. Biochemical analysis of gel-forming mucins from respiratory secretions of horses with recurrent airway obstruction (RAO)

Congratulations to Adele for winning the prize for the best poster at this congress.

Other news

Andreas Prokop was a key organiser of the nEUroskeleton initiative of about 70 research groups Europe-wide, and of its first informal meeting in Brussels on the 27 January, including talks with EU officials. The initiative aims to promote the neuronal cytoskeleton as a funding area in the Horizon 2020 programme.

Congratulations to...

Luke Bonser for successfully defending his PhD thesis entitled ‘The assembly and processing of polymeric mucins’ supervised by Dave Thornton. Luke is moving to the US to take up a postdoc position in David Erle’s lab at UCSF.

Public engagement

Friday 3 February saw the Centre run its first event of this year's public programme: 'Genes to Phenotypes'. With our biggest turn out yet, 40 A'-level students from across Greater Manchester came along to work with Ray Boot-Handford, Louise Kung, Lorna Mullan and Becki Holley and learn about the Centre's research into short-limbed dwarfism. Students tried their hand at histology analysis, DNA sequencing and identifying phenotypes by measuring bone length. In the second half of the session, A'-level students met Douglas Dyer, Lisa Brackenbury, Rawshan Choudhury, Jen Thompson and Sam Roberts to learn more about their research in our ever-competitive 'Meet the Scientist' event. With votes tied in the first round between Doug and Sam, Lisa romped home in the second round to secure almost 60% of the votes! Many thanks to all those who volunteered their time to make this such a success. Friday 10 February sees the second round of Genes to Phenotypes...so watch this space!

Andreas Prokop hosted the University Board of Governers in the Fly Core Facility to explain the importance of using fruitflies in research. Michael Smith and Scott Walker presented posters at the same event. The feedback from the visitors was very positive.