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TSG-6 is a pleotropic regulator of chemokine-GAG interactions

We have discovered that in addition to CCL5, CXCL8 and CXCL11, TSG-6 interacts with at least 7 other chemokines (i.e. CCL2, CCL7, CCL19, CCL21, CCL27, CXCL4, and CXCL12) including those involved in both homeostatic and inflammatory functions. TSG-6 interacts (via its Link module) with the Read more

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The circadian clock is essential for healthy cartilage

Our studies showed that in human knee cartilage the expression of a core circadian clock protein BMAL1 was progressively decreased in diseased joints. To investigate what happens to cartilage when it is devoid of circadian rhythm we created a transgenic mouse with selective deletion of Bmal1 mainly Read more