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Back pain link to 24-hour body clock revealed

New research has for the first time shown that our spinal discs have 24-hour body clocks which when they malfunction, can contribute to lower back pain. Lower back pain is amongst the most prevalent spinal diseases associated with increasing age, with over 80% of the UK population predicted to Read more

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Inbuilt body clocks link breast stiffness to cancer risks

We have discovered that breast tissues have 24-hour body clocks, and that several hundred genes are regulated in a daily cycle. The discovery may offer the first evidence of a link between breast biology - including breast cancer risks - and the body clock. We found that ageing of breast tissue has Read more

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TSG-6 is a pleotropic regulator of chemokine-GAG interactions

We have discovered that in addition to CCL5, CXCL8 and CXCL11, TSG-6 interacts with at least 7 other chemokines (i.e. CCL2, CCL7, CCL19, CCL21, CCL27, CXCL4, and CXCL12) including those involved in both homeostatic and inflammatory functions. TSG-6 interacts (via its Link module) with the Read more

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Why our organs are bendy

Clair Baldock, along with a team of researchers from Sydney and MIT, has discovered how one of the body’s crucial building blocks allows human tissues to be so flexible. We now have a better understanding of how elastin – which makes our organs and vessels flexible - moves. Read more

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The circadian clock is essential for healthy cartilage

Our studies showed that in human knee cartilage the expression of a core circadian clock protein BMAL1 was progressively decreased in diseased joints. To investigate what happens to cartilage when it is devoid of circadian rhythm we created a transgenic mouse with selective deletion of Bmal1 mainly Read more