The Wellcome Trust Centre for Cell-Matrix Research is an interdisciplinary research centre embedded within the Faculty of Life Sciences at the University of Manchester. The Centre was established in 1995, supported by a generous grant from the Wellcome Trust, with the long-term aims of elucidating the structure and function of extracellular matrices and cell-matrix adhesions, defining the contributions of cell-matrix interactions to human diseases, and developing approaches for preventing and treating these diseases. Initially, under the chairmanship of Professor Mike Grant, the Centre comprised 16 research groups with a total of 80 research staff. The Directorship of the Centre passed to Professor Martin Humphries in 2000, then to Professor Charles Streuli in late 2009. Professor Karl Kadler took over as Director in September 2015. In January 2004 the Centre relocated to the new Michael Smith building, named after a former graduate of the University of Manchester and 1993 Nobel Laureate in Chemistry.