About us


An interdisciplinary research centre embedded within the Faculty of Life Sciences at The University of Manchester.

Research Themes


Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease. 

For everyone

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Learn all about the Immortality exhibition, a art-science collaboration between Sally Gilford and the Centre, on YouTube Read more

Our discoveries

Our core facilities

Our public engagement activities

Our research

Our publications

Latest News

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The Wellcome Trust Institutional Strategic Support in partnership with the Public Programmes Team at the Nowgen Centre hosted a celebration event showcasing and exploring creative engagement with research. Sally Gilford attended to showcase her ongoing exhibition ‘Immortality’ in collaboration with Tony Day, Christoph Ballestrem and Andrew Gilmore. There were over 60 attendees from across the University and creative practitioners from further afield all keen to explore new and innovative Read more

Upcoming events


9th June - Jenny Nichols, University of Cambridge.  22nd June - Herbert Schiller, Max Planck Institute of Biochemistry, Martinsried.  "Systems Biology of the Extracellular Niche in Chronic Lung Disease" Read more

Latest Discoveries


The polysaccharide hyaluronan (HA) plays a crucial role in the formation of an elastic and hydrated matrix that forms around the oocyte prior to its release from the ovary. The correct assembly and mechanical properties of this matrix are necessary for successful ovulation, transport of the oocyte into the oviduct and for fertilisation. Previous research has identified three proteins involved in the stabilisation of this matrix – inter-a-inhibitor (IaI), TSG-6 and pentraxin-3 – but how they Read more

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Circadian clocks control all sorts of aspects of our physiology and they help our bodies to anticipate for changes that occur in the 24-hour day. In fact they have a crucial role in many tissues. However, very little is known about what circadian clocks do in tissues such as tendon, or what happens if they go wrong. Read more