Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease.
The Cell-Matrix Centre sends its congratulations to the Manchester Museum on their recent success in winning the Lever Prize 2015. The prize was awarded for the Real Life Science project, which the Cell-Matrix Centre contributes significantly to through the 'Engage with the Expert' series of workshops. These workshops give students from across schools and colleges in Greater Manchester the opportunity to work alongside researchers from the Cell-Matrix Centre in a range of interactive workshops, Read more
Thursday 9 April saw Islington Mill host 'Immortality', a Work in Progress Exhibition by Sally Gilford in collaboration with the Centre. The exhibition was bustling all evening, with music and refreshments and lots of talk about what inspired the exhibition. Thanks to all those who came along. Next exhibition date tbc… Read more
Jeremy Green, Professor of Developmental Biology, King's College London. Research interests:Molecular signals controlling cell polarity and spatial organisation in embryonic development. Specifically, the interaction of morphogen signals, especially the Wnt pathway, with polarity proteins such as PAR-1, atypical protein kinase C (aPKC) and PAR-4 (Lkb1) in the development of the early nervous system and body axis. Xenopus (frog) embryos are used because of their large size and accessibility. Read more
NRF2 is a redox-sensitive master transcription factor, which controls a battery of antioxidants and detoxification enzymes. Disrupting the NRF2 pathway is critical for the pathogenesis of several chronic pulmonary diseases. Read more
Collagen is the main structural protein in connective tissues in animals and exists as ordered bundles of fibrils in tendons, ligaments, bone and skin. Collagen fibrils can be several millimeters in length, making them the longest, largest and most size-variable polymers known. Until now, the precise cellular location of their manufacture and the transport of these large proteins was not understood. Read more