About us

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An interdisciplinary research centre embedded within the Faculty of Life Sciences at The University of Manchester.

For everyone

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'Get Connected’ the annual conference of the Wellcome Trust Centre for Cell-Matrix Research was held In Manchester between 10-12th September 2014. The focus of the meeting this year was the cellular microenvironment, one of the Centre’s key themes. The programme was masterfully designed and organised by Holly Brunton (PDRA in the Wellbrock lab), Ed Horton (PhD student in the Humphries Lab) and Ahmet Ucar (PDRA in the Streuli lab) and the event, attended by 80 participants, was a huge success. Read more

Our discoveries

Our core facilities

Our public engagement activities

Our research

Our publications

Latest News

Grants awarded:  Tony Day, Fight for Sight/National Eye Research Centre Small Grant Award. Investigating epigenetic modifications in the etiology of age-related macular degeneration.                                                                                                    Cay Kielty, MRC Clinical Capability Call ‘Single Cell Research Centre’, 2015-2020, to establish a ground-breaking Single Cell Research Centre (SCRC), more details at MRC Read more

Upcoming events

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'Formin-g the cytoarchitecture of the heart in health and disease' Read more

Latest Discoveries

 
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Collagen is the main structural protein in connective tissues in animals and exists as ordered bundles of fibrils in tendons, ligaments, bone and skin. Collagen fibrils can be several millimeters in length, making them the longest, largest and most size-variable polymers known. Until now, the precise cellular location of their manufacture and the transport of these large proteins was not understood. Read more

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The ubiquitous polysaccharide hyaluronan (HA) has an essential role in the organisation of matrix structure via its interaction with specific HA-binding proteins (HABPs). TSG-6 is an HABP that is expressed in response to inflammatory signals and protects tissues from the damaging effects of inflammation. Our previous work has found that TSG-6 can cause a major reorganisation of HA-rich matrices, but the precise mechanism underlying this was unknown.  Read more