Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease.
Members of the Centre ran the Body Experience at the Manchester Museum on Saturday 26th March. 8 hours, 16 stands, 67 researchers, 15 volunteers, 2 science buskers, 540 passports, one brilliant day! Watch here https://storify.com/CeriHarrop/body-experience Read more
Laminins are large heterotrimeric extracellular matrix proteins essential for correct formation of basement membranes. Binding of the c-termini of laminins to cells occurs via two mechanisms; either integrin- or dystroglycan-mediated. Loss of dystroglycan-mediated laminin-binding results in aberrant formation of basement membranes. This leads to particularly severe forms of muscular dystrophy, called dystroglycanopathies (including Walker-Warburg syndrome) and other pathologies such as kidney Read more
We have now identified a crucial molecular pathway by which Tregs dampen ongoing inflammation. Thus, expression of the cell surface molecule integrin αvβ8 is upregulated by Tregs that are themselves activated in the inflammatory environment, and this enables the Tregs to activate high levels of the cytokine TGFβ. This pathway is absolutely required for Tregs to dampen ongoing inflammation in mice, and also appears to be conserved in humans. We have therefore identified an important pathway by Read more