About us


An interdisciplinary research centre embedded within the Faculty of Life Sciences at The University of Manchester.

Job opportunities in the Centre

Vacancy for Professorial Chair in Cell-Matrix Research
A major new cell matrix research role, working with funding from the Wellcome Trust. Read more

Independent Research Fellows Call
We offer an attractive and flexible fellowship scheme for potential fellows who are competitive for external fellowships, or independent research fellows who have substantive external funding. Read more

For everyone


We have established an exciting new collaboration with screen print artist, Sally Gilford of One69A to be exhibited in North Tea Power in the Northern Quarter in Manchester from the summer 2014.     Read more

Our discoveries

Our core facilities

Our public engagement activities

Our research

Our publications

Latest News

Grants:    Tony Day co-applicant with Paul Bishop, Simon Clark, Richard D. Unwin, Andrwe Dowsey, Graeme Black and Garth Cooper, Fight for Sight Project Grant, Sep 2014 - Aug 2017, Elucidation of molecular mechanisms underpinning disease initiation and progression in age related macular degeneration.            Cay Kielty, Wellcome Trust ISSF, Sep 2014 - Aug 2015, ADAMTS10 mutant mice for genotype-phenotype studies and cell/gene therapy advances.           Cay Kielty, MRC Confidence in Read more

Upcoming events


The Cellular Matrix Microenvironment, 10-12 September 2014. The conference organisers, Holly Brunton (Wellbrock lab), Ed Horton (Humphries lab) and Ahmet Ucar (Streuli lab), have produced a fantastic programme with eight sessions all based on the microenvironment theme. Read more

Latest Discoveries


Stem cells have enormous potential to be used in the treatment of a wide variety of diseases because of their ability to convert into many different types of cell. However, this kind of “regenerative medicine”, which is sometimes called tissue engineering, requires the ability to direct their conversion into the cell type of choice. This has proved very difficult to achieve because we do not sufficiently understand what controls the conversion process or what dictates the type of cell that is Read more

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Melanoma is responsible for over 90% of skin cancer deaths. Today the most prominent genetic changes in melanoma have been characterised. This helped to identify a group of proteins called the MAP-kinase signalling module as the main driver of melanoma development. Currently inhibitors for the protein MEK, which is one component of this module, are being evaluated in the clinic. However, MAP-kinase signalling is important for all cells and not only for melanoma cells. Therefore, higher doses of Read more