About us

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An interdisciplinary research centre embedded within the Faculty of Life Sciences at The University of Manchester.

Research Themes

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Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease. 

For everyone

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Members of the Centre ran the Body Experience at the Manchester Museum on Saturday 26th March. 8 hours, 16 stands, 67 researchers, 15 volunteers, 2 science buskers, 540 passports, one brilliant day! Watch here https://storify.com/CeriHarrop/body-experience Read more

Our discoveries

Our core facilities

Our public engagement activities

Our research

Our publications

Latest News

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Recent conversations with the Whitworth Art Gallery have led to an exciting new collaborative opportunity for the Cell-Matrix to work with the gallery and present a week-long interactive workshop exploring 'What makes us human?'. This workshop will build on the ever-popular Masterclass workshops, aimed at Primary School audiences with the goal of using our research to inspire art and reciprocally using art to express what makes us human.  Read more

Upcoming events

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Michael Sixt's laboratory is interested in morphodynamic processes both at the cellular and at the tissue level. We mainly focus on the immune system and try to understand the molecular and mechanical principles underlying leukocyte dynamics during processes such as migration and intercellular communication. Here we work at the interface of cell biology, immunology and biophysics and currently investigate how the cytoskeleton generates force to deform the cell body, how this force is transduced Read more

Latest Discoveries

 
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The body of an animal is a highly organised structure of tissues and organs that contain cells with specialised roles. To achieve this level of organisation, it is important that embryos can establish a front-to-back axis which involves bone morphogenetic proteins (BMPs). BMPs bind to other proteins to provide instructions to cells, but there are inhibitory molecules that can trap BMPs. These inhibitors, and enzymes that break down the inhibitors (i.e. Tolloids), create a gradient of BMP Read more

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By following up the role of one of these changes, we have determined that active integrin complexes establish an environment that stabilises microtubules at the cell periphery. Read more