About us

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An interdisciplinary research centre embedded within the Faculty of Life Sciences at The University of Manchester.

Job opportunities in the Centre

Vacancy for Professorial Chair in Cell-Matrix Research
A major new cell matrix research role, working with funding from the Wellcome Trust. Read more

Independent Research Fellows Call
We offer an attractive and flexible fellowship scheme for potential fellows who are competitive for external fellowships, or independent research fellows who have substantive external funding. Read more

For everyone

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We have established an exciting new collaboration with screen print artist, Sally Gilford of One69A to be exhibited in North Tea Power in the Northern Quarter in Manchester from the summer 2014.     Read more

Our discoveries

Our core facilities

Our public engagement activities

Our research

Our publications

Latest News

Grants:    Tony Day co-applicant with Paul Bishop, Simon Clark, Richard D. Unwin, Andrwe Dowsey, Graeme Black and Garth Cooper, Fight for Sight Project Grant, Sep 2014 - Aug 2017, Elucidation of molecular mechanisms underpinning disease initiation and progression in age related macular degeneration.            Cay Kielty, Wellcome Trust ISSF, Sep 2014 - Aug 2015, ADAMTS10 mutant mice for genotype-phenotype studies and cell/gene therapy advances.           Cay Kielty, MRC Confidence in Read more

Upcoming events

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The Cellular Matrix Microenvironment, 10-12 September 2014. The conference organisers, Holly Brunton (Wellbrock lab), Ed Horton (Humphries lab) and Ahmet Ucar (Streuli lab), have produced a fantastic programme with eight sessions all based on the microenvironment theme. Read more

Latest Discoveries

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Melanoma is responsible for over 90% of skin cancer deaths. Today the most prominent genetic changes in melanoma have been characterised. This helped to identify a group of proteins called the MAP-kinase signalling module as the main driver of melanoma development. Currently inhibitors for the protein MEK, which is one component of this module, are being evaluated in the clinic. However, MAP-kinase signalling is important for all cells and not only for melanoma cells. Therefore, higher doses of Read more

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Collagen is the main structural protein in connective tissues in animals and exists as ordered bundles of fibrils in tendons, ligaments, bone and skin. Collagen fibrils can be several millimeters in length, making them the longest, largest and most size-variable polymers known. Until now, the precise cellular location of their manufacture and the transport of these large proteins was not understood. Read more