Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease.
The Cell-Matrix Centre sends its congratulations to the Manchester Museum on their recent success in winning the Lever Prize 2015. The prize was awarded for the Real Life Science project, which the Cell-Matrix Centre contributes significantly to through the 'Engage with the Expert' series of workshops. These workshops give students from across schools and colleges in Greater Manchester the opportunity to work alongside researchers from the Cell-Matrix Centre in a range of interactive workshops, Read more
Hilary Ashe, Ellie Shuttleworth and Sarah Woolner attended the meeting of the Burnage Reading Group on Friday 6 February to discuss The Immortal Life of Henrietta Lacks by Rebecca Skloot. Feedback from the evening speaks for itself: I run the reading group which the 3 researchers came to last Friday and just wanted to say what an excellent evening we had. Several of the ladies I’ve seen since then have all been talking about the science, astonished to find themselves so interested after the Read more
Unwinding the ‘Death-Inducing Signalling Complex’: a crucial role for DED chain assembly in regulating life/death decisions Read more
Circadian clocks control all sorts of aspects of our physiology and they help our bodies to anticipate for changes that occur in the 24-hour day. In fact they have a crucial role in many tissues. However, very little is known about what circadian clocks do in tissues such as tendon, or what happens if they go wrong. Read more
Age-related Macular Degeneration (AMD) is one of the commonest causes of blindness in developed countries and develops after the age of 50. There is strong evidence, that in some individuals, poor regulation of the innate immune system leads to tissue damage in the central part of the retina (called the macula) with the loss of central vision. Our earlier work showed that a common genetic variant in the gene for complement factor H (CFH) affected the ability of this crucial regulatory protein to Read more