Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease.
Friday 30 September saw a take-over of the Manchester Museum for European Researchers Night. The Grencis & Thornton Labs (Eamon Dubiassi, Maya Glover, Gareth Hughes) hosted a brilliant interactive stand all about their research on mucus and the microbiome. Jade Whittingham-Dowd gave a talk on mucus in the Lightening Talks in The Study whilst Rebecca Shears and Dave Thornton entertained and inspired the public in the Science Bar. Read more
The family-focussed take-over of the Manchester Museum that is Body Experience will go ahead for the 7th year running on 18 March 2017 at the Manchester Museum. We will fill the museum with all things biology, medicine and health. For those of you who are not familiar, here is a taster. Read more
Mesenchymal progenitor cells have potential in regenerative medicine, but improved characterisation of these cells is needed. We have defined the cell-matrix interface of mesenchymal stromal cells (MSCs) and umbilical cord perivascular cells (HUCPVC) by quantitative proteomics Read more
We have discovered that in addition to CCL5, CXCL8 and CXCL11, TSG-6 interacts with at least 7 other chemokines (i.e. CCL2, CCL7, CCL19, CCL21, CCL27, CXCL4, and CXCL12) including those involved in both homeostatic and inflammatory functions. TSG-6 interacts (via its Link module) with the GAG-binding site on the chemokines, thereby inhibiting the binding of chemokines to GAGs and their presentation on endothelial cells; TSG-6 also inhibits the binding of chemokines to collagen, providing another Read more