About us


An interdisciplinary research centre embedded within the Faculty of Life Sciences at The University of Manchester.

Job opportunities in the Centre

Vacancy for Professorial Chair in Cell-Matrix Research
A major new cell matrix research role, working with funding from the Wellcome Trust. Read more

Independent Research Fellows Call
We offer an attractive and flexible fellowship scheme for potential fellows who are competitive for external fellowships, or independent research fellows who have substantive external funding. Read more

For everyone


We have established an exciting new collaboration with screen print artist, Sally Gilford of One69A to be exhibited in North Tea Power in the Northern Quarter in Manchester from the summer 2014.     Read more

Our discoveries

Our core facilities

Our public engagement activities

Our research

Our publications

Latest News

Grants:    Tony Day co-applicant with Paul Bishop, Simon Clark, Richard D. Unwin, Andrwe Dowsey, Graeme Black and Garth Cooper, Fight for Sight Project Grant, Sep 2014 - Aug 2017, Elucidation of molecular mechanisms underpinning disease initiation and progression in age related macular degeneration.            Cay Kielty, Wellcome Trust ISSF, Sep 2014 - Aug 2015, ADAMTS10 mutant mice for genotype-phenotype studies and cell/gene therapy advances.           Cay Kielty, MRC Confidence in Read more

Upcoming events


The Cellular Matrix Microenvironment, 10-12 September 2014. The conference organisers, Holly Brunton (Wellbrock lab), Ed Horton (Humphries lab) and Ahmet Ucar (Streuli lab), have produced a fantastic programme with eight sessions all based on the microenvironment theme. Read more

Latest Discoveries


Our innate immune system provides a first line of defense against many different types of microorganisms. Part of this system is the so-called “complement cascade”, which has an important role in the removal of pathogens as well as the body’s own dead cells. However unwanted activation of complement can damage healthy tissues, and needs to be carefully controlled. A protein termed complement factor H (CFH) can distinguish a host cell from an invading bacteria. CFH does this by recognizing Read more


The oocyte (or ‘egg’) can be regarded as the single most important cell in the human body, as it carries the mother’s genes on to the next generation. During ovulation, a special jelly-like extracellular matrix protects the oocyte. The matrix is made up from a mixture of hyaluronan (HA), which is a sugar polymer, and at least three different proteins: TSG-6, IaI and PTX-3. These proteins help organise the HA, but if any one of these proteins is defective, the matrix doesn’t form correctly, and Read more