About us

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An interdisciplinary research centre embedded within the Faculty of Life Sciences at The University of Manchester.

For everyone

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'Get Connected’ the annual conference of the Wellcome Trust Centre for Cell-Matrix Research was held In Manchester between 10-12th September 2014. The focus of the meeting this year was the cellular microenvironment, one of the Centre’s key themes. The programme was masterfully designed and organised by Holly Brunton (PDRA in the Wellbrock lab), Ed Horton (PhD student in the Humphries Lab) and Ahmet Ucar (PDRA in the Streuli lab) and the event, attended by 80 participants, was a huge success. Read more

Our discoveries

Our core facilities

Our public engagement activities

Our research

Our publications

Latest News

Grants awarded:  Tony Day, Fight for Sight/National Eye Research Centre Small Grant Award. Investigating epigenetic modifications in the etiology of age-related macular degeneration.                                                                                                    Cay Kielty, MRC Clinical Capability Call ‘Single Cell Research Centre’, 2015-2020, to establish a ground-breaking Single Cell Research Centre (SCRC), more details at MRC Read more

Upcoming events

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'Formin-g the cytoarchitecture of the heart in health and disease' Read more

Latest Discoveries

 
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The kidney glomerulus is a highly sophisticated filter, which allows water and small molecules to pass freely while retaining cells and large molecules in the circulation. The glomerulus contains unique cells and extracellular matrix components and these are affected across a wide spectrum of glomerular disease. Whilst histological patterns of matrix change are described for different glomerular disorders, the mechanisms leading to altered matrix are incompletely understood. Read more

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Age-related Macular Degeneration (AMD) is one of the commonest causes of blindness in developed countries and develops after the age of 50. There is strong evidence, that in some individuals, poor regulation of the innate immune system leads to tissue damage in the central part of the retina (called the macula) with the loss of central vision. Our earlier work showed that a common genetic variant in the gene for complement factor H (CFH) affected the ability of this crucial regulatory protein to Read more