About us


An interdisciplinary research centre embedded within the Faculty of Life Sciences at The University of Manchester.

For everyone


'Get Connected’ the annual conference of the Wellcome Trust Centre for Cell-Matrix Research was held In Manchester between 10-12th September 2014. The focus of the meeting this year was the cellular microenvironment, one of the Centre’s key themes. The programme was masterfully designed and organised by Holly Brunton (PDRA in the Wellbrock lab), Ed Horton (PhD student in the Humphries Lab) and Ahmet Ucar (PDRA in the Streuli lab) and the event, attended by 80 participants, was a huge success. Read more

Our discoveries

Our core facilities

Our public engagement activities

Our research

Our publications

Latest News

download (1)-ce8d98b390beaf0e208dfab79f7b5a11.jpeg

Grants awarded:     Cay Kielty, UK Regenerative Medicine Platform, “Engineering and Exploiting the Stem Cell Niche” Hub. Extracellular matrix products for niche biomaterials and biology (2014-2016).  Read more

Upcoming events

Autumn 2014-3111eedba94e3c494f2cf6d6bfd11fe5.jpg

Nan Yang (Meng/Streuli labs) & Yutaka Matsubayashi (Millard Lab) Read more

Latest Discoveries


Cells sense their extracellular environment using integrin receptors. Integrins are linked to the cell’s intracellular cytoskeleton via proteins arranged in large multi-protein complexes called focal adhesions. The physical properties of the extracellular matrix control fundamental cellular processes, such as cell division and migration. However the molecular basis of how integrins transduce mechanical stimuli from the ECM, and how this leads to a coordination of focal adhesions, is unclear. Read more


Age-related Macular Degeneration (AMD) is one of the commonest causes of blindness in developed countries and develops after the age of 50. There is strong evidence, that in some individuals, poor regulation of the innate immune system leads to tissue damage in the central part of the retina (called the macula) with the loss of central vision. Our earlier work showed that a common genetic variant in the gene for complement factor H (CFH) affected the ability of this crucial regulatory protein to Read more