Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease.
'Get Connected’ the annual conference of the Wellcome Trust Centre for Cell-Matrix Research was held In Manchester between 10-12th September 2014. The focus of the meeting this year was the cellular microenvironment, one of the Centre’s key themes. The programme was masterfully designed and organised by Holly Brunton (PDRA in the Wellbrock lab), Ed Horton (PhD student in the Humphries Lab) and Ahmet Ucar (PDRA in the Streuli lab) and the event, attended by 80 participants, was a huge success. Read more
Cell Signaling by Extracellular Matrix Stiffness: Mechanical forces play a critical role in regulating cellular function. In vivo, cells are exposed to mechanical forces as a consequence of blood flow, blood pressure, and extracellular matrix (ECM) stiffness. Read more
The kidney glomerulus is a highly sophisticated filter, which allows water and small molecules to pass freely while retaining cells and large molecules in the circulation. The glomerulus contains unique cells and extracellular matrix components and these are affected across a wide spectrum of glomerular disease. Whilst histological patterns of matrix change are described for different glomerular disorders, the mechanisms leading to altered matrix are incompletely understood. Read more
Neutrophils play an essential role in the inflammatory response to injury/infection, but their destructive potential requires that their migration from the vasculature into tissues is tightly regulated to avoid unwanted damage. The chemokine CXCL8, which is produced in response to pro-inflammatory stimuli, interacts with glycosaminoglycans (GAGs) such as heparan sulphate (HS) on the vascular endothelium to form a ‘haptotactic’ gradient that guides neutrophil recruitment. The Read more