Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease.
Grants awarded: Tom Jowitt and Rachel Lennon (with Paul Brenchley and Edward Mckenzie), Kidney Research UK, August 2015-August 2018. Blocking PLA2R receptor activation on podocytes with soluble epitope peptide can modulate the pathological effects of anti-PLA2R: a new therapy for preventing relapse in membranous nephropathy Read more
Melanoma is the most deadly form of skin cancer because melanoma cells are highly invasive and spread easily. It was always thought that melanoma cells can be divided into invasive and non-invasive cells, and that these properties can be extrapolated to a whole tumour. Read more
Melanoma is the most deadly form of skin cancer with around 13,300 people diagnosed in the UK each year. Recently novel ‘targeted’ therapies using small molecule inhibitors have been developed, which are very effective in a large group of patients. Unfortunately, patients often stop responding at some point, because they develop resistance to these novel targeted drugs. Read more