About us

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An interdisciplinary research centre embedded within the Faculty of Life Sciences at The University of Manchester.

Research Themes

Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease. 

For everyone

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Members of the Centre ran the Body Experience at the Manchester Museum on Saturday 26th March. 8 hours, 16 stands, 67 researchers, 15 volunteers, 2 science buskers, 540 passports, one brilliant day! Watch here https://storify.com/CeriHarrop/body-experience Read more

Our discoveries

Our core facilities

Our public engagement activities

Our research

Our publications

Latest News

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Visitors to the Centre:   Adi Shiloah from Elazar Zelzer’s lab at the Weizmann Institute visited the Kadler Lab from 3-6 May to learn IMOD and 3D reconstruction as part of the Lord Alliance collaboration between WTCCMR and the Weizmann Institute, Israel.  Read more

Upcoming events

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Laminins are large heterotrimeric extracellular matrix proteins essential for correct formation of basement membranes. Binding of the c-termini of laminins to cells occurs via two mechanisms; either integrin- or dystroglycan-mediated. Loss of dystroglycan-mediated laminin-binding results in aberrant formation of basement membranes. This leads to particularly severe forms of muscular dystrophy, called dystroglycanopathies (including Walker-Warburg syndrome) and other pathologies such as kidney Read more

Latest Discoveries

 
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We have now identified a crucial molecular pathway by which Tregs dampen ongoing inflammation. Thus, expression of the cell surface molecule integrin αvβ8 is upregulated by Tregs that are themselves activated in the inflammatory environment, and this enables the Tregs to activate high levels of the cytokine TGFβ. This pathway is absolutely required for Tregs to dampen ongoing inflammation in mice, and also appears to be conserved in humans. We have therefore identified an important pathway by Read more

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By following up the role of one of these changes, we have determined that active integrin complexes establish an environment that stabilises microtubules at the cell periphery. Read more