About us

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An interdisciplinary research centre embedded within the Faculty of Life Sciences at The University of Manchester.

Job opportunities in the Centre

Vacancy for Professorial Chair in Cell-Matrix Research
A major new cell matrix research role, working with funding from the Wellcome Trust. Read more

Independent Research Fellows Call
We offer an attractive and flexible fellowship scheme for potential fellows who are competitive for external fellowships, or independent research fellows who have substantive external funding. Read more

For everyone

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The end of November saw our very first book club on 'The Immortal Life of Henrietta Lacks'.  Other book groups have shown much interest so this will run into the New Year and beyond.   Read more

Our discoveries

Our core facilities

Our public engagement activities

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Latest News

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Grants awarded                                                                            Cay Kielty, MRC project grant, May 2014-June 2017. Pericellular mechanisms of fibrillin microfibril assembly               Press release                                                              Pekovic-Vaughan, V., Gibbs, J., Yoshitane, H., Yang, N., Pathiranage, D., Guo, B., Sagami, A., Taguchi, K., Bechtold, D., Loudon, A., Yamamoto, M., Chan, J., van der Horst, G.T., Fukada, Y. and Meng, Q.J. Read more

Upcoming events

Adding new branches to the vascular tree: organ-specific angiogenesis Read more

Latest Discoveries

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Stem cells have enormous potential to be used in the treatment of a wide variety of diseases because of their ability to convert into many different types of cell. However, this kind of “regenerative medicine”, which is sometimes called tissue engineering, requires the ability to direct their conversion into the cell type of choice. This has proved very difficult to achieve because we do not sufficiently understand what controls the conversion process or what dictates the type of cell that is Read more

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Almost all cells are preprogramed to commit suicide if they become damaged. This process, called apoptosis, has to be tightly regulated to ensure that the death programme only becomes activated in cells that need to die. Apoptosis is controlled by mitochondria, whose primary function is to generate ATP. Mitochondria also contain proteins such as cytochrome c, which can kill cells by apoptosis if it is released into the cytosol. When cells become damaged, a group of proteins collectively termed Read more