Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease.
The Cell-Matrix Centre sends its congratulations to the Manchester Museum on their recent success in winning the Lever Prize 2015. The prize was awarded for the Real Life Science project, which the Cell-Matrix Centre contributes significantly to through the 'Engage with the Expert' series of workshops. These workshops give students from across schools and colleges in Greater Manchester the opportunity to work alongside researchers from the Cell-Matrix Centre in a range of interactive workshops, Read more
The extracellular matrix fine-tunes the innate immune response to infection Read more
Age-related Macular Degeneration (AMD) is one of the commonest causes of blindness in developed countries and develops after the age of 50. There is strong evidence, that in some individuals, poor regulation of the innate immune system leads to tissue damage in the central part of the retina (called the macula) with the loss of central vision. Our earlier work showed that a common genetic variant in the gene for complement factor H (CFH) affected the ability of this crucial regulatory protein to Read more
Collagen is the main structural protein in connective tissues in animals and exists as ordered bundles of fibrils in tendons, ligaments, bone and skin. Collagen fibrils can be several millimeters in length, making them the longest, largest and most size-variable polymers known. Until now, the precise cellular location of their manufacture and the transport of these large proteins was not understood. Read more