Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease.
Members of the Centre ran the Body Experience at the Manchester Museum on Saturday 26th March. 8 hours, 16 stands, 67 researchers, 15 volunteers, 2 science buskers, 540 passports, one brilliant day! Watch here https://storify.com/CeriHarrop/body-experience Read more
Join artists and scientists to discover, play and create together with your family this summer at the Whitworth. Explore what makes us human and how living things respond to the world around them. Look at the Whitworth with new eyes together with scientists and get closer than ever to our collections. Be inspired by patterns in art and nature to create your own colourful artworks to take home. This event is drop-in and designed for all ages. 11am-3pm and will be held on Tuesday 26th July Read more
We have discovered that in addition to CCL5, CXCL8 and CXCL11, TSG-6 interacts with at least 7 other chemokines (i.e. CCL2, CCL7, CCL19, CCL21, CCL27, CXCL4, and CXCL12) including those involved in both homeostatic and inflammatory functions. TSG-6 interacts (via its Link module) with the GAG-binding site on the chemokines, thereby inhibiting the binding of chemokines to GAGs and their presentation on endothelial cells; TSG-6 also inhibits the binding of chemokines to collagen, providing another Read more
We have now identified a crucial molecular pathway by which Tregs dampen ongoing inflammation. Thus, expression of the cell surface molecule integrin αvβ8 is upregulated by Tregs that are themselves activated in the inflammatory environment, and this enables the Tregs to activate high levels of the cytokine TGFβ. This pathway is absolutely required for Tregs to dampen ongoing inflammation in mice, and also appears to be conserved in humans. We have therefore identified an important pathway by Read more