About us

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An interdisciplinary research centre embedded within the Faculty of Biology, Medicine and Health at The University of Manchester.

Research Themes

Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease. 

For everyone

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Friday 30 September saw a take-over of the Manchester Museum for European Researchers Night. The Grencis & Thornton Labs (Eamon Dubiassi, Maya Glover, Gareth Hughes) hosted a brilliant interactive stand all about their research on mucus and the microbiome. Jade Whittingham-Dowd gave a talk on mucus in the Lightening Talks in The Study whilst Rebecca Shears and Dave Thornton entertained and inspired the public in the Science Bar.  Read more

Our discoveries

Our core facilities

Our public engagement activities

Our research

Our publications

Latest News

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The family-focussed take-over of the Manchester Museum that is Body Experience will go ahead for the 7th year running on 18 March 2017 at the Manchester Museum. We will fill the museum with all things biology, medicine and health. For those of you who are not familiar, here is a taster. Read more

Upcoming events

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John Couchman, University of Copenhagen "Syndecans – gatekeepers of the cell adhesion phenotype" Read more

Latest Discoveries

 
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Mesenchymal progenitor cells have potential in regenerative medicine, but improved characterisation of these cells is needed. We have defined the cell-matrix interface of mesenchymal stromal cells (MSCs) and umbilical cord perivascular cells (HUCPVC) by quantitative proteomics Read more

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We have discovered that in addition to CCL5, CXCL8 and CXCL11, TSG-6 interacts with at least 7 other chemokines (i.e. CCL2, CCL7, CCL19, CCL21, CCL27, CXCL4, and CXCL12) including those involved in both homeostatic and inflammatory functions. TSG-6 interacts (via its Link module) with the GAG-binding site on the chemokines, thereby inhibiting the binding of chemokines to GAGs and their presentation on endothelial cells; TSG-6 also inhibits the binding of chemokines to collagen, providing another Read more