Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease.
This year as part of the British Science Week celebrations, the Centre along with colleagues from across FBMH took over Manchester Museum for the Body Experience. With people waiting for the doors to open at 10am, the visitors were non-stop! The Thornton, Lennon, Streuli, Gilmore and Swift labs worked incredibly hard entertaining and inspiring the public all day. We saw over 2000 visitors, handed out 750 passports and 500 bags, hosted over 80 researchers across 18 stands with 12 volunteers Read more
Congratulations to Christoph Ballestrem, Martin Humphries and Mark Travis on their successful BBSRC grant applications! The Centre held it’s summer symposium on 15 June and a big thank you to all the postdocs and students who responded to the call for abstracts. A small team of Group Leaders selected 6 talks that represent research across the Centre. The quality of the abstracts was superb and it was a difficult task to select just 6 (see photo, from L-R: Hamish Gilbert, Richa Garva, Charlene Read more
The Wellcome Centre for Cell-Matrix Research will host the sixth of our popular Get Connected Research symposia and this year the focus will be Matrix in Fibrosis. There will be 3 thematic sessions covering Mechano- Immuno- and Disease-matrix and we have an excellent faculty of invited speakers. Read more
We have discovered that breast tissues have 24-hour body clocks, and that several hundred genes are regulated in a daily cycle. The discovery may offer the first evidence of a link between breast biology - including breast cancer risks - and the body clock. We found that ageing of breast tissue has a central role in controlling these clocks. Read more
Our studies showed that in human knee cartilage the expression of a core circadian clock protein BMAL1 was progressively decreased in diseased joints. To investigate what happens to cartilage when it is devoid of circadian rhythm we created a transgenic mouse with selective deletion of Bmal1 mainly in cartilage cells. The tissue-specific Bmal1 deletion led to profound degeneration of articular cartilage in the knees. Gene expression analysis of normal and mutant cartilage showed that many Read more