Vision: To determine the mechanisms underpinning how cell-matrix interactions control normal tissue formation and function, and how their disruption causes disease.
The Centre will take part in the coveted European Researchers Night event, Science Uncovered, this year hosted by the Manchester Museum. The event will take place between 6pm and 10pm on Friday 25th September. Come and explore just how crucial mucus is in protecting our bodies from the outside world. Read more
Grants awarded: Tom Jowitt and Rachel Lennon (with Paul Brenchley and Edward Mckenzie), Kidney Research UK, August 2015-August 2018. Blocking PLA2R receptor activation on podocytes with soluble epitope peptide can modulate the pathological effects of anti-PLA2R: a new therapy for preventing relapse in membranous nephropathy Read more
'Get Connected’ the annual conference of the Wellcome Trust Centre for Cell-Matrix Research, will be held 16-18 September 2015 and is based on the Chrono-Matrix theme and is entitled Timing, timing, timing: the dynamics of cell-matrix interaction. Keynote speakers will be John O'Neill, Karl Kadler, Maria Dolores (Lola) Martin-Bermudo, Paul Potter, Andy Blanchard, Matthew Hardman, David Whitmore and Martha Merrow. Read more
Melanoma is the most deadly form of skin cancer with around 13,300 people diagnosed in the UK each year. Recently novel ‘targeted’ therapies using small molecule inhibitors have been developed, which are very effective in a large group of patients. Unfortunately, patients often stop responding at some point, because they develop resistance to these novel targeted drugs. Read more
Methods to measure gene expression such as RNA-Seq and microarrays are commonly used to help understand mechanisms of disease. It can be challenging to interpret how the large amount of genes that are found to be significantly altered in a complex disease, such as osteoarthritis, act together to produce the observed symptoms. Systems biology aims to integrate various types of biological data to provide a global view of cellular processes. There are many genes which when mutated cause known Read more